Folinic acid for chronic fatigue syndrome and fibromyalgia.
Comment: Folinic acid (5-formyl tetrahydrofolate) is an activated form of folic acid. In certain circumstances, when the conversion of folic acid to its active forms is blocked, folinic acid is an effective treatment even though folic acid is not. In addition, some people have a defect in the transport of folic acid across the blood-brain barrier into the brain, because they make antibodies that block the folate receptors in the choroid plexus. In those people, treatment with folinic acid corrects cerebral folate deficiency by bypassing the folic acid transport mechanism. There is no clear evidence that people with fibromyalgia or chronic fatigue syndrome have a defect in folic acid absorption, transport, or utilization. However, considering the apparent effectiveness of folinic acid in the treatment of these conditions, such a possibility should be investigated. Controlled trials are needed to confirm the efficacy of folinic acid.
Lundell K, et al. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399-404.
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|Title Annotation:||Literature Review & Commentary|
|Author:||Gaby, Alan R.|
|Article Type:||Brief article|
|Date:||Feb 1, 2008|
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