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Fluoroquinolones linked to abnormal blood glucose levels.

TAIWAN -- Fluoroquinolones have been associated with higher rates of severe hyperglycemia (high blood glucose levels) and hypoglycemia (low blood glucose levels) than other classes of antibiotics in patients with diabetes. Among the fluoroquinolone class, moxifloxacin (Avelox[R]) carried the greatest risk.

Investigators used national health insurance claims from 2006 and 2007 from Taiwan to identify all patients with diabetes who received a new prescription for an oral fluoroquinolone, a second-generation cephalosporin, or a macrolide. Severe dysglycemia was defined as an episode of hyperglycemia or hypoglycemia resulting in a visit to the emergency department or hospitalization within 30 days after the start of antibiotic treatment. Fluoroquinolones, but not cephalosporins, showed a significantly increased risk of dysglycemia relative to macrolides, the reference drug category.

Gatifloxacin (Tequin[R]) was withdrawn from the market in 2006 because of its association with dysglycemia, and these antibiotics may cause hypoglycemia by increasing the body's release of insulin.

(Source: Clinical Infectious Diseases, August 15, 2013.)

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Publication:Nutrition Health Review
Geographic Code:9TAIW
Date:Jun 22, 2012
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