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Feinstein Institute secures USD1.65m to identify and examine vagus nerve's role in sepsis.

M2 EQUITYBITES-August 17, 2018-Feinstein Institute secures USD1.65m to identify and examine vagus nerve's role in sepsis


Medical research company Feinstein Institute for Medical Research reported on Thursday the receipt of a USD1.65m grant from the National Institutes of Health (NIH) to examine the vagus nerve's role in the inflammation and metabolism associated with sepsis, a body-wide immune system reaction to an infection responsible for deaths.

This five-year, USD1.65m NIH R01 grant was awarded to the institute's medical research professor Valentin A. Pavlov, PhD.

Having a better understanding of the nervous system's signalling during sepsis could lead to the identification of new therapeutic targets within bioelectronic medicine, which combines neuroscience, molecular biology and bioengineering to tap into the nervous system to treat disease and injury without pharmaceuticals.

In conjunction, the previous research conducted by Dr Pavlov and Feinstein Institute president and CEO Dr Kevin J. Tracey, MD, found that the brain and the vagus nerve are involved in controlling immune responses and inflammation - this discovery has been called the inflammatory reflex.

Dr Pavlov's team plans to map the neural signals coming from the brainstem through the vagus nerve to the body's organs during sepsis. In this new study, he will examine the role of the vagus nerve originating in the brainstem in the regulation of immune responses and metabolism during sepsis.

Through combined work, Feinstein's researchers have identified a protocol, which includes early administration of fluids and antibiotics, to implement across Northwell Health's 23 hospitals. As a result, sepsis-related mortalities at those facilities have been reduced by almost 70%.

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Publication:M2 EquityBites (EQB)
Date:Aug 17, 2018
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