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Family clustering of avian influenza A (HSN1).

To the Editor: The unprecedented epizootic of avian influenza A (H5N1) in Asia poses a serious threat of causing the next global influenza pandemic. H5N1 viruses, to which humans have little or no immunity, have demonstrated the capacity to infect humans and cause severe illness and death (1-4). Fortunately, these viruses have not yet demonstrated the capacity for efficient and sustained person-to-person transmission, although limited person-to-person transmission was the cause of at least 1 family cluster of cases (5). Since family clusters of H5N1 illness may be the first suggestion of a viral or epidemiologic change, we have been monitoring them with great interest.

Through our regional contacts and public sources, we have monitored family clusters and other aspects of H5N1 in Southeast Asia. A cluster was defined as [greater than or equal to] 2 family members with laboratory-confirmed H5N1 or [greater than or equal to] 2 family members with severe pneumonia or respiratory death, at least one of which had confirmed H5N1. To determine if family cluster events had increased over time, we divided the number of cluster events by the total number of days in 2 discrete periods and calculated rate ratios (RR) and 95% confidence intervals (CI). To determine whether the increase in family clustering was attributable to an increase in the number of cases, we divided the number of family units with [greater than or equal to] 2 laboratory-confirmed cases by the total number of family units in the period. Percentage of deaths was also compared.

From January 2004 to July 2005, 109 cases of avian influenza A (H5N1) were officially reported to the World Health Organization (WHO) (6). During this time, 15 family clusters were identified (Table). Of the 11 (73%) clusters that occurred in Vietnam, 7 were in northern Vietnam. Cluster size ranged from 2 to 5 persons, and 9 (60%) had [greater than or equal to] 2 persons with laboratory-confirmed H5N1. Cluster 6 in Thailand was well documented and was likely the result of limited person-to-person transmission (5). For the other clusters, epidemiologic information was insufficient to determine whether person-to-person transmission occurred. In at least 3 clusters in Vietnam (Table; clusters 5, 7, and 11), >7 days occurred between the onset of the first and the next case, suggesting that simultaneous acquisition from a common source was unlikely. In cluster 11, 2 nurses assisted in the care of the index case-patient and subsequently were hospitalized with severe pneumonia; 1 had laboratory-confirmed H5N1.

Family clusters were slightly more likely to have occurred between December 2004 and July 2005 than in the first year of the outbreak (9 clusters in 243 days or 3.7 per 100 days vs. 6 clusters in 365 days or 1.6 per 100 days, respectively; RR 2.3, 95% CI 0.8-6.3). The difference was similar when the periods were limited to the same 8 months, 1 year apart (RR 1.8, 95% CI 0.6-5.4). Twenty-five (61%) of the 41 patients in the 15 family clusters died; the 7 persons who recovered or were not ill experienced secondary cases.

Family clusters are still occurring; however, they do not appear to be increasing as a proportion of total cases. The proportion of families that were part of a cluster was similar from December 2004 to July 2005 to the proportion in the first year (6/55, 11% vs. 3/41, 7%, respectively, p = 0.7). However, the proportion of deaths dropped significantly, from 32 of 44 (73%) during December 2003 to November 2004, to 23 of 65 (35%) during December 2004 to July 2005 (p<0.0001).

Although reports of H5N1 family clusters slightly increased, the increase was not statistically significant. Nevertheless, we believe any cluster of cases is of great concern and should be promptly and thoroughly investigated because it might be the first indication of viral mutations resulting in more efficient person-to-person spread. Family clustering does not necessarily indicate person-to-person transmission, as it may also result from common household exposures to the same H5N1-infected poultry or from other exposures, such as to uncooked poultry products.

The decrease in proportion of deaths during 2005 is another epidemiologic change that should be monitored closely because it may reflect viral adaptation to the human host. Surveillance for human cases of avian influenza has been intensified in recent months, perhaps resulting in the identification of less severe cases. Alternatively, more widespread laboratory testing may be associated with false-positive results. No evidence to date shows genetic reassortment between H5N1 and human influenza A viruses (7). Viruses isolated from case-patients need to be immediately sequenced and characterized in relation to previously circulating viruses to see whether they are evolving.

Recent modeling studies suggest that containing a pandemic at its source may be possible because emergent pandemic viruses may be less transmissible than commonly assumed (8), and antiviral treatment and chemoprophylaxis may slow the spread (9). Although the logistics of an attempt to contain the beginning of a potential influenza pandemic are formidable, we believe it is not beyond the capability of the modern global public health system. As WHO (10) has called for, countries should intensify their pandemic preparedness plans and strengthen international collaborations.

Sonja J. Olsen, * Kumnuan Ungchusak, ([dagger]) Ly Sovann, ([double dagger]) Timothy M. Uyeki, ([section]) Scott F. Dowell, * Nancy J. Cox, ([section]) William Aldis, ([paragraph]) and Supamit Chunsuttiwat ([dagger])

* International Emerging Infections Program, Nonthaburi, Thailand; ([dagger]) Ministry of Public Health, Nonthaburi, Thailand; ([double dagger]) Ministry of Health, Phnom Penh, Cambodia; ([dagger]) Centers for Disease Control and Prevention, Atlanta, Georgia, USA; and ([paragraph]) World Health Organization, Nonthaburi, Thailand


(1.) Hien TT, de Jong M, Farrar J. Avian influenza--a challenge to global health care structures. N Engl J Med. 2004;351: 2363-5.

(2.) Centers for Disease Control and Prevention. Cases of influenza A (H5N1--Thailand, 2004. MMWR Morb Mortal Wkly Rep. 2004;53:100-3.

(3.) Chokephaibulkit K, Uiprasertkul M, Puthavathana P, Chearskul P, Auewarakul P, Dowell SF, et al. A child with avian influenza A (H5N1) infection. Pediatr Infect Dis J. 2005 ;24:162-6.

(4.) Chotpitayasunondh T, Ungchusak K, Hanshaoworakul W, Chunsuthiwat S, Sawanpanyalert P, Kijphati R, et al. Human disease from influenza A (H5N 1), Thailand, 2004. Emerg Infect Dis. 2005; 11:201-9.

(5.) Ungchusak K, Auewarakul P, Dowell SF, Kitphati R, Auwanit W, Puthavathana P, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med. 2005;352:333-40.

(6.) World Health Organization. Cumulative number of confirmed human cases of avian influenza A/(H5N 1) reported to WHO. Vol. 2005. Geneva: The Organization; 2005. [cited 2005 Sep 22]. Available from enza/country/cases_table_2005 07 27/en/i ndex.html

(7.) World Health Organization. Evolution of H5N1 avian influenza viruses in Asia. Emerg Infect Dis. 2005;11:1515-21.

(8.) Mills CE, Robins JM, Lipsitch M. Transmissibility of 1918 pandemic influenza. Nature. 2004;432:904-6.

(9.) Longini IM Jr, Nizam A, Xu S, Ungchusak K, Hanshaoworakul W, Cummings DA, et al. Containing pandemic influenza at the source. Science. 2005 Aug 12;309:1083-7. Epub 2005 Aug 3.

(10.) World Health Organization. Influenza pandemic preparedness and response. Geneva: The Organization; 2005. [cited 2005 Sep 22]. Available from ebwha/pdf_files/EB 115/B 115_44-en.pdf

Address for correspondence: Sonja J. Olsen, CDC, Box 68, American Embassy, APO AP 96546; fax: 66-2-580-0911; email: SOlsen@
Table. Family clusters of influenza A (H5N1) in Southeast Asia,
January 2004-July 2005 *

Cluster Onset of index case Country Age (y)/Sex

 1 Dec 03 Vietnam (N) 12/F
 2 Dec 03 Vietnam (N) 5/M
 3 Jan 04 Vietnam (N) 31/M
 4 Jan 04 Thailand 6/M
 5 Jul 04 Vietnam (S) 19/M
 6 Sep 04 Thailand 11/F
 7 Dec 04 Vietnam (N) 46/M
 8 Jan 05 Vietnam (S) 17/M
 9 Jan 05 Vietnam (S) 35/F
10 Jan 05 Cambodia 14/M
11 Feb 05 Vietnam (N) 21/M
12 Feb 05 Vietnam (N) 69/M
13 Mar 05 Vietnam 13/F
14 Mar 05 Vietnam (N) 39/M
 4 mo/NN
15 Jul 05 Indonesia 8/F

 Relation to
Cluster index case H5N1 Onset

 1 Self + Dec 25
 Mother + Jan 1
 2 Self + Dec 29 ([dagger])
 Sister NT NN
 3 Self NT Jan 7 ([dagger])
 Sister + Jan 10
 Wife + Jan 10
 Sister + Jan 11
 4 Self + Jan 8
 Mother NT Jan 8
 5 Self NT Jul 23
 Cousin NT NN
 Sister + Jul 31
 6 Self NT Sep 2
 Mother + Sep 11
 Aunt + Sep 16
 7 Self + Dec 26
 Brother + Jan 10 ([dagger])
 Brother + Not ill
 8 Self + Jan 10 ([dagger])
 Sister NN NN
 9 Self + Jan 14
 Daughter + Jan 20
10 Self NT NN
 Sister + Jan 21
11 Self + Feb 14
 Sister + Feb 23
 Grandfather + Not ill
12 Self + Feb 19
 Wife + Not ill
13 Self NT Mar 9 ([section])
 Brother + Mar 12 ([dagger])
 Aunt P NN
14 Self + Mar 22 ([dagger])
 Wife + Mar 22 ([dagger])
 Child + Mar 22 ([dagger])
 Child + Mar 22 ([dagger])
 Child + Mar 22 ([dagger])
15 Self + ([paragraph]) Jun 24
 Sister NT Jun 29
 Father + Jul 12

Cluster Outcome

 1 D
 2 D
 3 D
 4 D
 5 D
 6 D
 7 D
 Not ill
 8 D
 Unknown ([double dagger])
 9 D
10 D
11 Unknown ([double dagger])
 Unknown ([double dagger])
 Not ill
12 D
 Not ill
13 D
 Unknown ([double dagger])
14 Unknown ([double dagger])
 Unknown ([double dagger])
 Unknown ([double dagger])
 Unknown ([double dagger])
 Unknown ([double dagger])
15 D

* D, respiratory death; N, north; NT, not tested; NN, not noted; P,
pending; R, recovered; S, south.

([dagger]) Date of hospitalization.

([double dagger]) Had respiratory symptoms, was hospitalized (unknown
for #13), and outcome was unknown.

([section]) Date of death.

([paragraph]) Serologically confirmed; classified as a probable case by
the World Health Organization.
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Author:Chunsuttiwat, Supamit
Publication:Emerging Infectious Diseases
Article Type:Letter to the Editor
Date:Nov 1, 2005
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