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FROST & SULLIVAN MARKET INTELLIGENCE: WORLD HUMAN VACCINE MARKET TO GROW 16 PERCENT, TOP $5 BILLION BY 1999

 MOUNTAIN VIEW, Calif., July 21 /PRNewswire/ -- The worldwide human vaccine market will see accelerating growth, nearly tripling from $1.8 billion in 1992 to $5.3 billion by 1999 with a combined annual growth rate of more than 16 percent, forecasts a new report just released by Frost & Sullivan Market Intelligence.
 Growth rates will rise from just more than 10 percent in 1993 to 20 percent late in the decade, projects the report, "World Human Vaccine Markets."
 Geographic distribution of the world market will remain fairly stable. In 1992, 48 percent of global sales were accounted for by the U.S., 28 percent Europe and 24 percent other regions. These breakdowns reflect the bifurcation of world markets in which commercial manufacturers sell human vaccines mainly in the industrialized world with national governments and health organizations providing vaccines in developing countries.
 New technologies will drive the market through the 1990s. New vaccines will prevent diseases in ways not previously thought possible and technological advances will improve vaccine efficacy, during of effect and delivery.
 The majority of human vaccines are produced and distributed within the same country of origin, although international distribution is growing. Commercial manufacturers will step up their efforts to expand international sales through joint ventures, acquisitions of foreign manufacturers and creation of new offshore subsidiaries.
 Human vaccine manufacturers must creatively promote essentially commodity products to differentiate themselves. The competitive focus in the years ahead will be toward achieving technological advances, gaining government approvals and participating in winning acquisitions and collaborations.
 Exciting new developments are foreseen particularly concerning new vaccines against HIV, hepatitis C, herpes, malaria, lyme disease and cytomegaloviruses.
 Combination vaccines will gain further attention and popularity as manufacturers race to gain approval for combinations of as many antigens as possible.
 Recombinant development techniques will help stimulate growth. Additive components like adjuvants will heighten the efficacy of existing vaccines and facilitate production of vaccines previously unreliable or hard to produce. The use of conjugate technology is also expanding into new market areas and immunogenic vectors are being used as antigen carriers in new vaccines.
 Breakthrough technologies have brought new competition and more collaborative agreements, joint ventures and takeovers. This will occur more frequently as new biotechnology companies tempt large vaccine manufacturers with their unique technological strengths.
 Frost & Sullivan Market Intelligence is an international high- technology research firm specializing in healthcare markets. All Frost & Sullivan Market Intelligence reports are based on extensive interviews with marketing and technical experts from selected companies in each market segment. Primary research is validated by thorough analysis of available secondary research. Frost & Sullivan Market Intelligence is one of the leading publishers worldwide of high-technology market research reports.
 Code: 240-52. Publication Date: July 1993. Price: $2,295
 MARKET INTELLIGENCE
 TOTAL MARKET FOR HUMAN VACCINES:
 REVENUE FORECASTS (WORLD), 1989-1999
 Year Revenues ($ Million) Revenue Growth Rate (percent)
 1989 1,392.3 ---
 1990 1,523.6 9.4
 1991 1,669.0 9.5
 1992 1,832.6 9.8
 1993 2,026.4 10.6
 1994 2,271.5 12.1
 1995 2,603.6 14.6
 1996 3,029.7 16.4
 1997 3,636.1 20.0
 1998 4,379.6 20.4
 1999 5,261.4 20.1
 Compound annual growth rate (1992-1999): 16.3 percent.
 NOTE: All figures are rounded. Source: Frost & Sullivan Market Intelligence.
 -0- 7/20/93
 /CONTACT: Amy Arnell of Frost & Sullivan Market Intelligence, 415-961-9000, or fax, 415-961-5042/


CO: Frost & Sullivan Market Intelligence ST: California IN: MTC SU:

SG-LH -- SJ001 -- 3884 07/21/93 11:01 EDT
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Date:Jul 21, 1993
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