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FOR FIRST TIME, USE OF NEW GENETICALLY ENGINEERED FERTILITY DRUG RESULTS IN PREGNANCY

 FOR FIRST TIME, USE OF NEW GENETICALLY ENGINEERED
 FERTILITY DRUG RESULTS IN PREGNANCY
 OSS, The Netherlands, May 14 /PRNewswire/ -- A major breakthrough in infertility treatment was recently marked by the world's first human single-embryo pregnancy achieved through treatment with a new recombinant fertility drug made by Organon International.
 The drug, which stimulates the ripening of ovarian follicles, is a genetically engineered form of follicle stimulating hormone (FSH). The new hormone is undergoing clinical investigation. FSH products currently available are derived from the urine of postmenopausal women, which Organon obtains through volunteer urine collection programs in The Netherlands.
 Production of the recombinant product would eliminate the process of collecting urine from thousands of women. Laboratory studies show that its activity is indistinguishable from that of the natural hormone.
 Success with recombinant FSH, reported in May 9, 1992, issue of The Lancet, was achieved in Belgium by Professor Paul Devroey and Professor Andre van Steirteghem at the Center for Reproductive Medicine of the Free University of Brussels.
 "Achievement of a pregnancy with recombinant FSH represents a major advance in treating female infertility -- one that may eventually help millions of couples who currently are unable to conceive," said Devroey.
 "After working many years to produce recombinant FSH, a copy of a very complex human molecule, we are proud to be the first company to make possible a pregnancy with this genetically engineered hormone," said Paul Lammers, M.D., M.Sc., director of professional services, Organon Inc. Lammers said that the company expects the recombinant form of the drug to be available in several years.
 A world leader in contraceptive and hormone research, Organon is a Netherlands-based global pharmaceutical company with U.S. headquarters located in West Orange, N.J. In addition to developing and marketing infertility products, Organon is one of only a small number of companies currently involved in basic, cutting-edge contraceptive research. The company is researching new methods of contraception, such as new contraceptive implants, and immune-contraception -- vaccines that will inhibit sperm from fertilizing an egg.
 Organon is a part of Akzo Pharma division.
 -0- 5/14/92
 /CONTACT: Craig Rothenberg of Organon, 201-325-4969, or Wendy Mensch of Edelman Medical Communications, 212-704-8196, for Organon/
 (AKZOY) CO: Organon Inc. ST: New Jersey IN: MTC SU:


PS-SM -- NY007 -- 0022 05/14/92 08:15 EDT
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Date:May 14, 1992
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