Printer Friendly

FDA Approves Drug Combo for Aggressive Thyroid Cancer; Dabrafenib + trametinib approved to treat BRAF-positive anaplastic thyroid cancer.

MONDAY, May 7, 2018 (HealthDay News) -- Two anti-cancer drugs administered together have been approved by the U.S. Food and Drug Administration to treat BRAF-positive anaplastic thyroid cancer.

Tafinlar (dabrafenib) and Mekinist (trametinib) combined have been approved to treat anaplastic thyroid cancer caused by an abnormal BRAF V600E gene, the agency said Friday in a news release. The same drug combination was approved previously to treat melanoma and non-small-cell lung cancer caused by abnormalities of the same gene.

Common side effects of the drug combination include: fever, rash, chills, headache, arthralgia, cough, fatigue, nausea, and diarrhea, the FDA said. More serious adverse reactions could include: development of new cancers, bleeding problems, heart problems, eye problems, skin reactions, high blood sugar, anemia, and blood clots. Since both drugs can harm a growing fetus, pregnant women and women who are expecting to become pregnant shouldn't take the therapy, the agency warned.

"This is the first FDA-approved treatment for patients with this aggressive form of thyroid cancer, and the third cancer with this specific gene mutation that this drug combination has been approved to treat," Richard Pazdur, M.D., director of the FDA's Oncology Center of Excellence and acting director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research, said in a statement. "This approval demonstrates that targeting the same molecular pathway in diverse diseases is an effective way to expedite the development of treatments that may help more patients."

Both drugs are produced by the Swiss drugmaker Novartis Pharmaceuticals.

More Information

COPYRIGHT 2018 HealthDay
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2018 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Physician's Briefings
Date:May 7, 2018
Words:257
Previous Article:Cancer Incidences and Burden Expected to Shift in HIV-Positive; Prostate and lung cancer expected to emerge as the most common types by 2030.
Next Article:Physical Therapy Helps Recover Arm Function in Chronic CVA; In chronic stroke patients, 4 weeks of PT associated with improved arm function,...
Topics:

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |