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Extreme weight gain in teens. (Clinical Capsules).

Extreme weight gain occurs frequently in adolescents with schizophrenia who are treated with olanzapine and risperidone, reported Dr. Gidi Ratzoni of the Shalvata Mental Health Center, Hod Hasharon, Israel, and colleagues.

In a prospective study of 50 adolescents (46 of whom had schizophrenia), 19 of 21 (91%) patients treated with olanzapine and 9 of 21(43%) treated with risperidone experienced weight gain of 7% or more. Only 1 of 8 (13%) patients treated with haloperidol during the 12-week, in-hospital treatment gained more than 7% of their baseline body weight (J. Am. Acad. Child Adolesc. Psychiatry 41 [3]:33 7-43, 2002).

The rate of weight gain increased the most in the first 4 weeks of treatment and subsequently diminished over the last 8 weeks. By week 12, patients in the olanzapine group gained a mean of 7.2 kg; patients in the risperidone group gained a mean of 3.9 kg; and those in the haloperidol group added a mean of 1.1 kg. By weeks 8 and 12, patients in the olanzapine group gained significantly more weight than those in the risperidone group.
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Author:Evans, Jeff
Publication:Clinical Psychiatry News
Article Type:Brief Article
Geographic Code:7ISRA
Date:Apr 1, 2002
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