Extract from gum resin of Boswellia serrata decreases [IA.sub.2]-antibody in a patient with "Late onset Autoimmune Diabetes of the Adult" (LADA).
Here we report a female patient, 50 years old with a body weight of 72 kg, where diabetes was first diagnosed on 16 November 2012. At this time blood glucose level was 390mg/dl and [HbA.sub.1c] 11.6%. The patient (see Table 1) was treated with Metformin, but there was no significant improvement of blood glucose and [HbA.sub.1c]. On 15th January 2013, testing for IA2-A which is a marker of insulitis--yielded 25 K/U/L suggesting a case of LADA. Therapy was changed to insulin (Humalog[TM], Huminsulin basal[TM]) 10-15 U per day. Thereafter blood glucose and [HbA.sub.1c] dropped significantly. Additional treatment of the patient with an alcoholic extract from the gum resin of B. serrata (Indian Boswellia the Original[TM]), (1) containing 3.6% KBA and 1.4% AKBA, (2) 3 times daily 2 tablets with 400 mg for 8.5 weeks resulted in a drop of [IA.sub.2]-A to normal values and in addition there was a further decrease of blood glucose and [HbA.sub.1c].
As far as the effect of the Boswellia extract on [1A.sub.2]-A is concerned, the data is in line with observations of Sharma et al. (1996) reporting, that boswellic acids inhibited antibody production in mice sensitized with sheep erythrocytes.
This is the first report where an extract of the resin of B. serrata not only prevents insulitis in animal models, but also seems to prevent insulitis in a patient with LADA as indicated by its action on a marker of autoimmune diabetes--in this case [IA.sub.2]-antibodies.
We are aware, that this is only one case with all its restrictions. But it may stimulate other attempts to strengthen the hypothesis that boswellic extracts or boswellic acids including KBA and AKBA may be an option for prevention/treatment of autoimmune diabetes.
Ammon, H.P.T., Shehata, A.M., 2011. Prevention of multiple low dose streptozotocin (MLD-STZ) induced diabetes in mice by extract from gum resin of Boswellia serrata and 11-keto-[beta]-boswellic acids. Diabetologia 54 (Suppl. 1), S437.
Shehata, A.M., Quintanilla-Fend, L, Bettio, S., Singh, C.B., Ammon, H.P.T., 2011. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE). Phytomedicine 18, 1037-1044.
Sharma, M.L., Kaul, A., Khajura, A., Singh, S., Singh, C.B., 1996. Immunmodulatory activity of boswellic acids (pentacyclic triterpene acids) from Boswellia serrata. Phytother. Res. 10, 107-112.
E. Schrott (a), S. Laufer (b), M. Lammerhofer (b), H.P.T. Ammon (c),*
(a) Steyrerweg 11,93049 Regensburg, Germany
(b) Department of Pharmaceutical and Medical Chemistry, Institute of Pharmaceutical Sciences, University of Tuebingen, Aufder Morgenstelle 8, 72076 Tuebingen, Germany
(c) Department of Pharmacology, Institute of Pharmaceutical Sciences, University of Tuebingen, Aufder Morgenstelle 8, 72076 Tuebingen, Germany
* Corresponding author at: Auf der Morgenstelle 8. 72076 Tubingen, Germany. Tel.: +49 07071 /2974675; fax: +49 07071/292476.
E-mail address: firstname.lastname@example.org (H.P.T. Ammon).
(1) Manufactured by Indian Boswellia Laboratory, Agra, India.
(2) Assayed with an Agilent 1100 LC-MSD-Trap combination.
Table 1 Extract from Gum Resin of Bosellila serrata normalizes Tyrosinphosphate [IA.sub.2]-Antibody. ([IA.sub.2]-A) in a Patient with Late-Onset Autoimmune Diabetes of the Adults (LADA). Time Schedule Blood HbA 1 c% [IA.sub.2]-A of Measurements glucose K/U/L and Therapy mg/dl 16.10.2012 391 11.9 -- 15.11.2012 391 11.6 -- 09.01.2013 333 13.7 -- 15.01.2013 -- -- 25 16.01.2013 -- -- -- 19.02.2013 107 -- -- 20.02.2013 -- -- -- 21.03.2013 129 7.3 -- 23.04.2013 84 -- -- 24.04.2013 70 -- 10 22.05.2013 -- -- 10 08.07.2013 99 6.2 -- Time Schedule Therapies of Measurements and Therapy 16.10.2012 Metformin 15.11.2012 09.01.2013 15.01.2013 16.01.2013 19.02.2013 20.02.2013 21.03.2013 Indian 23.04.2013 Boswellia[TM] Insulin 24.04.2013 22.05.2013 08.07.2013
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|Author:||Schrott, E.; Laufer, S.; Lammerhofer, M.; Ammon, H.P.T.|
|Publication:||Phytomedicine: International Journal of Phytotherapy & Phytopharmacology|
|Article Type:||Clinical report|
|Date:||May 15, 2014|
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