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Experimental Stem Cell Therapy Speeds Up Wound Healing in Diabetes.

NEW YORK, N.Y., January 3, 2019 -- The healing of wounded skin in diabetes can be sped up by more than 50 percent using injections of stem cells taken from bone marrow, a new study in mice shows.

The research, led by scientists at NYU School of Medicine, focused on a chain of events in diabetes that makes skin sores more likely to form and less likely to heal.

Namely, the body's failure in diabetes to break down dietary sugar creates molecules called free radicals that can wreak havoc on cells and damage their DNA.

These free radicals also trigger an inrush of immune cells and chemicals meant to fight infection that, researchers said, instead kill normal cells and cause diabetic skin ulcers that can take twice as long to heal as in healthy animals.

Citation: Piul S. Rabbani et al., Dysregulation of Nrf2/Keapl Redox Pathway in Diabetes Affects Multipotency of Stromal Cells. Diabetes, 2019 Jan; 68(1): 141-155. DOI: 10.2337/dbl8-0232

Abstract/Article: http://bit.ly/2VDoaTd

Contact: Piul S. Rabbani, piul.rabbani@nyumc.org; Daniel J. Ceradini, daniel.ceradini@nyumc.org

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Title Annotation:Preclinical Research Briefs
Publication:Stem Cell Research News
Date:Jan 28, 2019
Words:185
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