Evidence is accumulating that nonoxynol-9 is ineffective as a vaginal microbicide.
Evidence is accumulating that nonoxynol-9 is ineffective as a vaginal microbicide. Investigators in Cameroon randomly assigned 1,251 women at high risk for sexually transmitted disease to use either condoms alone or condoms plus a nonoxynol-9 gel. By the end of six months of follow-up, they found no differences between the groups in rates of new urogenital infections, gonorrhea infections or chlamydia infections. The findings are consistent with results of an earlier study in Cameroon. [Roddy RE et al., Effect of nonoxynol-9 on urogenital gonorrhea and chlamydial infection: a randomized controlled trial, JAMA, 2002, 287(9):1117-1122.]