Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus).
Evaluation of the thermal antinociceptive effects and pharmacokinetics after intramuscular administration of buprenorphine hydrochloride to cockatiels (Nymphicus hollandicus). Guzman DSM, Houck EL, DiMaio Knych HK, et al. Am J Vet Res. 2018;79:1239-1245.
Objective: To evaluate thermal antinociceptive effects and pharmacokinetics of buprenorphine hydrochloride after intramuscular administration to cockatiels (Nymphicus hollandicus).
Animals: 16 adult ([greater than or equal to] 2 years old) cockatiels (8 males and 8 females).
Procedures: Buprenorphine hydrochloride (0.3 mg/mL) at each of 3 doses (0.6, 1.2, and 1.8 mg/kg) and saline (0.9% NaCl) solution (control treatment) were administered intramuscularly to birds in a randomized within-subject complete crossover study. Foot withdrawal response to a thermal stimulus was determined before (baseline) and 0.5, 1.5, 3, and 6 hours after treatment administration. Agitation-sedation scores were also determined. For the pharmacokinetic analysis, buprenorphine (0.6 mg/kg) was administered intramuscularly to 12 of the birds, and blood samples were collected at 9 time points, ranging from 5 minutes to 9 hours after drug administration. Samples were analyzed with liquid chromatography-mass spectrometry. Pharmacokinetic parameters were calculated with commercial software.
Results: Buprenorphine at 0.6, 1.2, and 1.8 mg/ kg did not significantly change the thermal foot withdrawal response compared with the response for the control treatment. No significant change in agitation-sedation scores was detected between all doses of buprenorphine and the control treatment. Plasma buprenorphine concentrations were > 1 ng/ mL in all 4 birds evaluated at 9 hours.
Conclusions and clinical relevance: Buprenorphine at the doses evaluated did not significantly change the thermal nociceptive threshold for cockatiels or cause sedative or agitative effects. Additional studies with other pain assessments and drug doses are needed to evaluate the analgesic and adverse effects of buprenorphine in cockatiels and other avian species.
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|Title Annotation:||Selected Abstracts From the Literature|
|Publication:||Journal of Avian Medicine and Surgery|
|Date:||Mar 1, 2019|
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