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Evaluation of pain pressure threshold and widespread pain in chronic low back pain/Kronik bel agrisinda basinc agri esigi ve yaygin agrinin degerlendirilmesi.

Introduction

Chronic low back pain (CLBP) is one of the most common musculoskeletal disorders, which leads to disability and thus creates an economic burden in industrialized countries (1). Unfortunately, the techniques available to understand the underlying mechanism and severity have remained very limited. Furthermore, few patients with back pain have well-known structural or mechanical causes, and the correlation between the degree of structural or mechanical abnormality and the resultant pain, even among patients with structural abnormalities of the spinous elements, has not been well established (2-5). Detailed physical examination, including evaluation of pain sensitivity, is necessary to define the clinical picture of a patient with CLBP. Although pain sensitivity or, in other words, tenderness was accepted as a useful finding for evaluation of musculoskeletal disorders, it is not generally used in the assessment of patients with CLBP As the interpretation of tenderness with the traditional method (ie, manual palpation) is confusing and insufficient, an algometer was developed and used to determine the pressure pain sensitivity precisely. This method, algometry, is proven to be a reliable method by several studies (6,7).

Pain sensitivity varies in the general population. While some patients exhibit a high pain threshold, others have a low pain threshold (8-10). The central neuron mechanisms and peripheral mechanisms have been the focus of studies to identify the neural mechanism underlying the development of hypersensitivity in tissues, such as muscle tenderness (11). The response properties of the dorsal horn and brain stem neurons change due to continuous nociceptive input (12), altering the normal processing of nociceptive and non-nociceptive information. As a result, pain threshold may be lowered. Although several studies have suggested the involvement of central mechanisms in lowering pain pressure threshold (PPT) in musculoskeletal disorders, such as CLBP (13-15), the way by which the neuronal mechanisms cause widespread pain and hypersensitivity in patients with CLBP remains controversial. Widespread pain is commonly defined as pain presenting on both sides of the body, above and below the waist, and also involving the axial skeleton (16). Population-based studies suggest that chronic widespread pain is seen in 5% to 15% of the population (9). A number of studies reported that widespread pain may occur among patients with CLBP (4,15), whereas other studies also suggest that widespread pain may be a result of CLBP (17). Many factors, including demographic (18,19), psychosocial (20,21), environmental (22), and structural abnormalities (5,23), have been investigated to better understand the mechanism of hypersensitivity and widespread pain in patients with CLBP.

The primary purpose of this study was to determine differences in pain pressure threshold between patients with CLPB and healthy people, using a number of points in several regions anatomically related or unrelated to the lumbar spine. The study also aimed to show low PPT values and widespread pain sensitivity by testing pain pressure threshold in anatomically unrelated sites of patients with CLBP

Material and Methods

Seventy patients (44 female, 26 male) with CLBP and 62 healthy control subjects (33 female, 29 male) without a history of low back pain were enrolled in the study. The inclusion criteria for the CLBP group were low back pain for more than 6 months without pain radiation to the buttock and lower extremity and without any neurological sings. Demographic characteristics (gender, age, history of LBP) were recorded. All the subjects were evaluated through a routine neurological and physical examination. Additional inclusion criteria for both groups were age between 20 and 60 years; no spine surgery in the previous 6 months; no history of concurrent disorders causing low back pain; and no use of opioid analgesics, antidepressants, or anticonvulsant medications within the last 3 weeks prior to testing. The subjects reported no use of non-steroidal anti-inflammatory drugs within 24 hours before testing. Also, subjects who were diagnosed with fibromyalgia syndrome according to ACR criteria were excluded.

For all the subjects, 18 tender points (TP) defined by the American College of Rheumatology for fibromyalgia syndrome (16), 12 points for the sciatic valleix (bilateral middle point of gluteus maximus, middle point of the gluteal sulcus, middle and posterior point of thigh, popliteal fossa, middle and posterior point of cruris, middle point of Achilles tendon), and 4 lumbar paravertebral points (bilateral 2 cm lateral to the L2 and L4 spinous processes) were evaluated. An electronic pressure algometer (Algometer commander, JTech Medical, 4314 ZEVEX Park Line; Salt Lake City, UT 84123) was used to measure pressure pain threshold (PPT) with a stimulation surface area of 1 [cm.sup.2]. Three consecutive measurements were performed at each site, with 10 seconds of recovery time allowed between repeated applications. During the algometric measurements, the subjects were asked to say "yes" when the pain was experienced. The amount of pressure-causing pain was recorded as PPT in kg/ [cm.sup.2]. The subjects were fully informed about the investigation and how to do the measurements. All PPT measurements were made by the same investigator (SO). The investigator who performed PPT measurements was blinded to the patients' clinical information and examination. The subjects were required to lie down in a prone position for the lumbar and sciatic valleix measurements. For fibromyalgia tender point measurements, the subjects were sitting in a chair. The first fibromyalgia tender point measurements were performed; then, PPT measurements were carried out on the lumbar and sciatic valleix points.

The sum of PPT of 18 points for tender points, 12 points for the sciatic valleix, and 4 points for the lumbar paravertebrae were calculated separately as final scores in kg/[cm.sup.2].

Visual analog scale (VAS) was used to measure the low back pain intensity. The 10-cm scale was marked with "0" for no pain and "10" for worst imaginable pain. The patients with CLBP were asked to mark their pain intensity on the scale at the moment of the evaluation.

The study protocol was approved by the ethics reviewing committee guidelines of our university, and written informed consent was obtained from each subject. All the subjects were volunteers who were not compensated for their participation.

Statistical Analysis

Statistical analysis was performed with Statistical Package for the Social Sciences (SPSS) 18.0 software (SPSS, Inc., Chicago, IL, USA). Continuous variables were expressed as mean [+ or -] standard error of mean or median (minimum-maximum), and categorical variables were expressed as frequency and percent. Continuous variables were compared with the independent sample t test or Mann-Whitney U test, and categorical variables were compared using Pearson chi-square test. A p value of less than 0.05 was considered statistically significant for all tests. Optimal sample size was determined by power analysis with G power. Sample size was calculated for a two-sided test with a significance level of 5% and power of 80%.

Results

The mean age of the CLBP group was 37.6 years (SD=10.1), and the mean age of the healthy controls was 34.6 years (SD=9.6). There were no statistically significant differences between the mean age of the two groups (p=0.090). The mean duration of pain in the CLBP group was 5.8 years (SD=5.4), and the mean visual analog scale was 5.4 (SD=1.9).

The mean PPT values tended to be significantly lower for every site in the CLBP group than in the control group (p=0.001). The mean and standard deviation of PPT values obtained from all test sites have been presented in Table 1 below.

Women were found to have significantly lower PPT in the 18 fibromyalgia tender and 12 sciatic valleix points than men in both the patient group (p<0.001) and control group (p=0.001). There were no statistically significant differences between men and women for the 4 lumbar paravertebral points in the patient and control groups (p=0.098, p=0.097 respectively).

Discussion

Mechanical stimuli have been used to evaluate the sensitization of myofascial tissues, such as tender points, work-related myalgia, and fibromyalgia. Assessment of pain sensitivity with manual palpation is a simple technique but is difficult to standardize and shows moderate sensitivity. Additionally, the reliability of manual palpation depends on the application technique of the examiner (24). On the other hand, the use of a pressure algometry technique to assess the sensitization is increasing because of its proven efficiency and reliability in muscle pain syndromes (6,7). Pressure algometry enables the application of a known force to skin and underlying myofascial tissues. The gradually increasing force is applied over the target area until patients specify pain rather than pressure. Also, this device has been used in different areas of the body, such as the patellar tendon and abdominal wall, to assess pain pressure threshold (25,26).

Although many researchers have studied PPT in patients with low back pain (LBP), the mechanism of the widespread low level of PPT has not been clearly defined. Several studies investigated PPT at sites anatomically related and unrelated to the lumbar spine (1,4). Lower PPT values were determined in patients with LBP even at anatomically unrelated sites (1,4,27). In addition, the mechanism of pain pressure threshold was studied at various anatomical sites in patients with chronic musculoskeletal conditions, such as LBP (1,4,11,27), fibromyalgia (28), strain injuries (29), rheumatoid arthritis (30), and osteoarthritis (31). Central sensitization may be determined using a number of palpable trigger points. Bajaj et al. (32) found a significantly higher number of trigger points in the lower limb muscles in patients with knee osteoarthritis than in the healthy controls.

A number of studies have shown central sensitization to be responsible for sensory threshold changes and widespread tenderness, as well as peripheral sensitization (13,14,33). Tissue damage stimulates the release of numerous inflammatory mediators from neurons and immune cells (34), resulting in activation of nociceptors in the injury area and nociceptor hypersensitivity. Increased nociceptor sensitivity is expressed by spontaneous firing, enlargement of the neuronal receptive field, and decreased firing threshold (35,36), which is known as the peripheral sensitization-an initiative for pain. Effective changes in tissue sensitivity may develop immediately after injury and the resultant pain because of neurobiological influences (14,37). Then, they may be followed by pain in unrelated sites and persistent exaggerated pain outside of the neuro-anatomical sensory distribution of the primary lesion. The change in threshold may be responsible for continuous pain rather than continuing tissue injury (38). On the other hand, people with persistent pain may experience secondary hypersensitivity at unrelated body sites outside of the injured tissue. In such cases, local nociceptive excitation and peripheral sensitization may coexist with a state of secondary hyperalgesia, leading to diffuse pain experience. This condition, known as central sensitization, contributes to diffuse hypersensitivity in regions beyond the damaged tissue (39).

The present study investigated PPT in a number of different sites to determine pain expected areas and pain-free control areas, such as tender points in upper sites of the body. The results of the study showed that patients with CLBP (CLBP group) had lower PPT values at every individual site compared with the healthy controls. All patients with CLBP showed significant generalized hyperalgesia when compared with the control group, which is compatible with the results of earlier studies showing low PPT values in chronic pain patients (1,4,28,32).

The findings of the study may be attributed to the development of central sensitization and maladaptive pain processing involving widespread hypersensitivity. The bombardment of neurons in the dorsal horn by the primary afferent system stimulates N-methyl-D-aspartate receptors and overwhelms pain control centers (40). The resultant neuronal plasticity in the dorsal horn and supraspinal regions contributes to spontaneous pain (38). Previous sub-threshold inputs from the somatosensory system begin to generate potentials from the dorsal horn to the central nerve system. Central sensitization is reinforced by the activation of low-threshold small-diameter primary afferents, thus allowing low-intensity stimulation to be perceived as pain and producing long-term changes in spinal neurons (41). Woolf et al. (42) have suggested three pathological mechanisms that might contribute to central sensitization: increased excitability, decreased inhibition, and structural reorganization of CNS. The combination of excitation and disinhibition causes persistent pain after a primary injury. People with CLBP had enhanced reactivity and reorganization of the somatosensory cortex with a positive relationship between cortical reactivity and chronicity (43). Giesbrecth et al. (1) suggested that biopsychosocial influences may have contributed to the differences in pain sensation between people with CLBP and people without pain. In the study of Peters et al. (44), those with CLBP were less sensitive to pressure stimuli than those without CLBP Very few points involving the index finger and right ankle were tested. Their findings contradict our findings. Nevertheless, in our study, local and distant points to the lumbar spine that were reliable were selected as test sites. Johansen et al. found lower PPT in the neck, shoulder, and tibial regions of subjects with whiplash-associated disorders (14). The results of the studies by Johansen and Bajaj are supportive of our findings (14,32). Our findings suggest that subjects with CLBP show significant global hypersensitivity compared with subjects without pain. Kasch et al. (29) have reported contrary results by measuring PPT in patients with acute whiplash and acute ankle distortion injury in the head and neck regions. The patients with acute whiplash injury had lower PPT at the head and neck sites up to 3 months, but there were no significant differences in PPT values in the 6 months following injury. They held peripheral sensitization responsible for hypersensitivity in the head and neck sites but reported no hypersensitivity in unrelated sites.

Conclusion

In conclusion, the current study points out that pain pressure thresholds measured in several regions anatomically related or unrelated to the lumbar spine in patients with chronic low back pain are significantly lower than those in healthy control subjects. It could be of great value to evaluate the presence of widespread pain in patients with chronic low back pain.

DOI: 10.5152/tftrd.2014.71602

Ethics Committee Approval: Ethics committee approval was received for this study from the ethics committee of Bulent Ecevit University Faculty of Medicine.

Informed Consent: Written informed consent was obtained from patients who participated in this study.

Peer-review: Externally peer-reviewed.

Author Contributions: Concept--S.O.; Design--S.O., S.S.; Supervision--S.S.; Materials--S.O., S.S.; Data Collection and/or Processing--S.O., S.S.; Analysis and/or Interpretation--F.K., S.O., S.S.; Literature Review--S.O.; Writer--S.O.; Critical Review--S.S.

Conflict of Interest: No conflict of interest was declared by the authors.

Financial Disclosure: The authors declared that this study has received no financial support.

Etik Komite Onayi: Bu calisma icin etik komite onayi Bulent Ecevit Universitesi Tip Fakultesi'nden alinmistir.

Hasta Onami: Yazili hasta onami bu calismaya katilan hastalardan alinmistir.

Hakem degerlendirmesi: Dis bagimsiz.

Yazar Katkilari: Fikir--S.O.; Tasarim--S.O., S.S.; Denetleme --S.S.; Malzemeler--S.O., S.S.; Veri toplanmasi ve/veya islemesi S.O., S.S.; Analiz ve/veya yorum--F.K., S.O., S.S.; Literatur taramasi ---S.O.; Yaziyi yazan--S.O.; Elestirel Inceleme--S.S.

Cikar Catismasi: Yazarlar cikar catismasi bildirmemislerdir.

Finansal Destek: Yazarlar bu calisma icin finansal destek almadiklarini beyan etmislerdir.

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Received/Gelis Tarihi: September/Eylul 2012 Accepted/Kabul Tarihi: February/Subat 2013

Senay OZDOLAP [1], Selda SARIKAYA [1], Furuzan KOKTURK [2]

[1] Department of Physical Medicine and Rehabilitation, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey

[2] Department of Biostatistics, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey

Address for Corespondance / Yazisma Adresi: Senay Ozdolap MD, Department of Physical Medicine and Rehabilitation, Bulent Ecevit University Faculty of Medicine, Zonguldak, Turkey. Phone: +90 372 261 24 50 E-mail: senayozd@yahoo.com
Table 1. Comparison of PPT controls in patients with CLBP and healthy

Test sites              CLBP                Control          p value
                    Group (n=70)          Group (n=62)

Fibromyalgia     87.2 [+ or -] 29.5   105.0 [+ or -] 31.6     0.001
tender
points

12 sciatic       78.5 [+ or -] 25.8    93.4 [+ or -] 26.1     0.001
valleix
points

4 lumbar         18.8 (6.03-62.40)      28.7 (6.6-46.2)      <0.001
paravertebral
points
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Title Annotation:Original Article/Orijinal Makale
Author:Ozdolap, Senay; Sarikaya, Selda; Kokturk, Furuzan
Publication:Turkish Journal of Physical Medicine and Rehabilitation
Article Type:Report
Geographic Code:7TURK
Date:Mar 1, 2014
Words:3905
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