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Evaluation of atrial conduction times, epicardial fat thickness and carotid intima-media thickness in patients with ankylosing spondylitis.

Ankylosing spondylitis (AS) is a chronic inflammatory disease with involvement of the sacroiliac joint and spine. It is noted that AS patients may additionally have cardiovascular system involvement. The prevalence of cardiovascular disease appears to reach 64%. (1) Though the underlying cause of the increase in cardiovascular pathologies has not been fully explained, it is thought that the chronic inflammatory process and autoimmunity play a part in this course. (2)

Atrial fibrillation (AF) is the most common arrhythmia type in the population. It is related to increased cardiac morbidity and mortality. (3) Pathophysiological mechanism leading to AF is electrical and/or structural remodeling developing in the atrium. (4) Studies have shown that AS patients have a tendency to develop AF. (5) Previous studies have reported that chronic inflammation eases the development of AF. However, there is still no consensus on whether AS can trigger atrial arrhythmias. (6,7) It is especially important to determine predisposing factors for AF development in this patient group.

Tissue Doppler echocardiography is a beneficial diagnostic tool used to determine atrial conduction times. (8) Using this technique, electromechanical delay (EMD) intervals are obtained for different areas of the atrium. Studies have proposed that many electrophysiological parameters including inter- and intraatrial EMD are predisposing factors for the development of AF. (9,10)

Atherosclerosis is the most frequent cause of coronary artery disease (CAD). It affects the medium- and large-diameter arteries in the body, in addition to the coronary arteries. Endothelial dysfunction and increased intima-media thickness are early findings of atherosclerosis. (11) Due to its easy application and non-invasive nature, carotid intima-media thickness (CIMT) is widely used with the aim of identifying subclinical atherosclerosis. (12) Epicardial fat thickness (EFT), forming as a result of visceral fat tissue accumulating around the heart, is a new cardiometabolic risk predictor. (13) In close contact with the myocardium, EFT works like a type of endocrine organ. (14) However, there appears to be no clear data in terms of atherosclerosis development related to EFT. (12,15) Accordingly, in this study, we aimed to determine the relationship between atrial EMD, CIMT, and EFT in AS, which has a complicated inflammatory nature.


A total of 42 patients (28 males, 14 females; mean age 39.3 [+ or -] 8.5 years; range 22 to 60 years) and 40 healthy controls (24 males, 16 females; mean age 37.2 [+ or -] 8.7 years; range 22 to 60 years) were included in the study. Control group was similar to the study group in terms of age and sex (both p>0.05). All participants were selected from the Departments of Physical Medicine and Rehabilitation and Cardiology of Abant Izzet Baysal University. They were diagnosed as AS on the basis of Assessment of SpondyloArthritis International Society criteria (5,12) between December 2014 and April 2015. This study was approved by our Institutional Ethics Committee. A written informed consent was obtained from each patient. The study was conducted in accordance with the principles of the Declaration of Helsinki.

Subjects with hypertension, diabetes, hypercholesterolemia, renal dysfunction, hypertriglyceridemia, connective tissue disease, and other inflammatory rheumatic diseases were excluded. All patients' electrocardiographies (ECG) were in sinus rhythm and patients were not taking any cardiac medications. We collected all blood specimens after 10 hour fasting. All participants were advised not to take heavy exercise and not to consume coffee, tea, energy drinks or alcohol before the examination. Serum lipid levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein level, and hepatic/renal function tests were measured.

Echocardiographic examinations of all individuals were performed by the same commercially available machine (Epiq7, Philips, 2-4 MHz phased array transducer) (Koninklijke Philips N.V., 2004-2016). During the evaluation of echocardiography, three-lead ECG was recorded simultaneously. M-mode measurements were applied according to criteria of American Society of Echocardiography. (16) Left atrium diameter, aortic root, ascendant aorta, left ventricular end-diastolic and end-systolic diameters were measured. Left ventricular ejection fraction was evaluated by Simpson's rule. (17) Pulsed-wave mitral flow velocities were evaluated from apical four-chamber view by inserting a sample volume on mitral leaflet tips. Mitral early diastolic velocity (E, cm/s), late diastolic velocity (A, cm/s), and E/A ratio were calculated.

Atrial electromechanical coupling is the time interval from the onset of P wave to the late diastolic wave on ECG. It was obtained from lateral mitral annulus, septal mitral annulus, and right ventricular tricuspid annulus and called as PA lateral, PA septum, and PA tricuspid, respectively. Interatrial EMD was measured by the difference between PA lateral and PA tricuspid. Left intraatrial EMD was measured by the difference between PA lateral and PA septum, and finally, right intraatrial EMD was measured by the difference between PA septum and PA tricuspid. (18,19) An average measurement was achieved after obtaining these values three times.

Epicardial fat thickness was measured by using echocardiography device (Epiq7, Philips, 2-4 MHz phased array transducer). We obtained EFT thickness in parasternal long axis window, from the right ventricular free wall at the end of the thickest location diastole.

The radiologist was blinded and CIMT was performed after a 10 minute rest, while patients were lying on their backs with their heads aligned 20 to 30[degrees] in the opposite direction. A radiologist obtained images using a Philips ClearVue 350 model Doppler ultrasonography device (Logiq S7 Expert, GE Healthcare, Wauwatosa, WI, USA) with 12-MHz linear transducer. Carotid intima-media thickness measurement was carried out when optimal longitudinal images could be obtained appropriately, 1 cm proximally from the common carotid artery bifurcation level and behind the posterior wall. The borders of the carotid artery lumen and adventitia were observed like double lines. Measurements were obtained between the echogenic line (intima) facing the lumen and the echogenic lines of the adventitia on the outside. We calculated the mean of the results obtained from three different points in both carotid arteries.

Statistical analysis

IBM SPSS software version 20.0 (IBM Corporation, Armonk, NY, USA) was used for statistical analysis. Continuous variables were presented as mean [+ or -] standard deviation while categorical variables were presented as n or ratio. Numerical variables of the groups were distributed normally, and variances were equal. Chi-square test was performed to compare categorical variables between the groups. Since the baseline demographics, laboratory and echocardiographic values were normally distributed; Student's t-test was performed to compare these parameters. P<0.05 was considered statistically significant.


According to the basic clinical and demographic characteristics, both groups were similar with regards to age, body mass index, heart rate, systolic blood pressure, diastolic blood pressure, smoking status, fasting glucose, and other biochemical parameters (Table 1).

Comparison of the baseline echocardiographic values are shown in Table 2. Interatrial (29.5 [+ or -] 5.8 ms vs. 17.9 [+ or -] 5.3 ms) left and right intraatrial EMD (18.2 [+ or -] 4.6 ms and 11.7 [+ or -] 3.5 ms vs. 11.9 [+ or -] 3.2 ms and 7.1 [+ or -] 3.2 ms, respectively) intervals were longer in AS patients than in healthy controls (all p<0.001). Left and right CIMT (0.50 [+ or -] 0.11 mm and 0.44 [+ or -] 0.06 mm vs. 0.51 [+ or -] 0.11 mm and 0.43 [+ or -] 0.04 mm, respectively) and EFT (0.73 [+ or -] 0.15 cm and 0.63 [+ or -] 0.07 cm) values were higher in AS patients than in healthy controls (all p<0.01). Left atrium diameter was higher in patients with AS than healthy controls (p=0.012). Epicardial fat thickness values and all measurements regarding atrial electromechanical coupling findings were higher in AS patients (Table 3). In addition, both CIMT values were higher in the patient group (Table 3).


To the best of our knowledge, this is the first study evaluating the parameters of atrial EMD, CIMT, and EFT values together in AS patients. In our study, we detected that the atrial EMD, CIMT, and EFT were increased in AS patients.

Cardiac involvement is a complication observed in AS patients. The most common occurrences are aortic root diseases and intracardiac conduction system anomalies. Increased myocardial fibrosis has been reported in AS patients. As a result, conduction system anomalies appear to be more significant compared to aortic root diseases. (20,21) Atrial conduction disorders developing linked to electrophysiological and electromechanical abnormalities increase risk of AF development. (9) According to recent studies, the intra- and interatrial electromechanical conduction times are higher in paroxysmal AF patients compared to a control group. (22,23)

A variety of etiologic factors have been shown to cause AF including genetic susceptibility, CAD, and cardiac toxins. (24-26) Together with these findings, recent studies have identified the presence of a relationship between chronic inflammation and AF development. In AF patients, infiltration of the atrial myocardium by inflammatory cells was observed. (27,28) In our study, we observed that the inter- and intraatrial conduction times were increased in the patient group. Abnormal increased activity has been shown in AS patients both in our study and previous studies. (29-32) It is predicted that these patients may have high risk for the development of AF. Though there is still no clear evidence, we believe that increased incidence of AF in AS patients may be related to chronic inflammation and increased myocardial fibrosis.

Epicardial fat thickness is thought to play an important role in the pathogenesis of CAD. Epicardial fat synthesizes many biologically active materials providing modulation of the vascular smooth muscle. The paracrine effects of these materials may be linked to their being close to the adventitia and extravascular bed. (14,33,34) Gastaldelli and Basta (14) showed a relationship between EFT and hypertension, atherosclerosis and CAD. Again, a study including 62 hemodialysis patients identified a strong relationship between CIMT and EFT thickness. (35) Nakanishi et al. (36) used computed tomography to measure EFT levels and reported that patients with high levels had more coronary artery calcification. In studies by Cece et al. (12) and Resorlu et al., (37) CIMT values in AS patients were found to be higher than those of the control group. In our study, AS patients had increased EFT thickness with high CIMT values. Based on these findings, we may conclude that AS patients with a tendency toward increased EFT thickness should be placed in the high-risk group in terms of CAD.

The main limitation of our study is the small sample size. In addition, AS patients could have been followed-up for a longer duration to observe possible cardiac complications.

In conclusion, patients with AS have an increased risk for cardiac involvement. We demonstrated that the atrial EMD, CIMT, and EFT were increased in AS patients. These factors might lead to the development of CAD, atherosclerosis and AF in AS patients. Therefore, AS patients should be examined by a cardiologist and undergo regular ECG and echocardiographic examinations for any cardiac involvement.

doi: 10.5606/ArchRheumatol.2016.5867

Declaration of conflicting interests

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.


The authors received no financial support for the research and/or authorship of this article.


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Sabri Onur CAGLAR, [1] Ismail BOYRAZ, [2] Fatma ERDEM, [1] Selma YAZICI, [2] Hilal CAGLAR, [2] Bunyamin KOC, [2] Emrah CAGLAR, [3] Mehmet YAZICI [1]

[1] Department of Cardiology, Abant Izzet Baysal Training and Research Hospital, Bolu, Turkey

[2] Department of Physical Medicine and Rehabilitation, Medical Faculty of Abant Izzet Baysal University, Bolu, Turkey

[3] Department of Radiology, Abant Izzet Baysal Training and Research Hospital, Bolu, Turkey

Received: December 22, 2015 Accepted: December 22, 2016 Published online: June 03, 2016

Correspondence: ismail Boyraz, MD. Abant izzet Baysal Universitesi Tip Fakultesi Fiziksel Tip ve Rehabilitasyon Anabilim Dali, 14280 Golkoy, Bolu, Turkey. Tel: +90 374-262 84 45 e-mail:
Table 1. Baseline characteristic of study subjects

Characteristic                        AS patient group (n = 42)

                                   n     %      Mean [+ or -] SD

Age (years)                                    39.4 [+ or -] 8.5
    Male                           28
    Female                         14
Body mass index (kg/[m.sup.2])                 23.9 [+ or -] 7.9
Smokers                                 28.5
Heart rate (beats/min)                         75.8 [+ or -] 7.9
Systolic blood pressure (mmHg)                 112.3 [+ or -] 9.1
Diastolic blood pressure (mmHg)                73.2 [+ or -] 6.1
Glucose (mg/dL)                                89.3 [+ or -] 7.1
White blood cells (x [10.sup.3]                 8.0 [+ or -] 1.8
Hemoglobin (g/dL)                              14.0 [+ or -] 1.8
Platelets (x [10.sup.6]/                        8.8 [+ or -] 3.3
Urea (mg/dL)                                   28.4 [+ or -] 9.3
Creatinine (mg/dL)                              0.9 [+ or -] 0.2
Triglyceride (mg/dL)                            124 [+ or -] 66
Total cholesterol (mg/dL)                       175 [+ or -] 38

Characteristic                          Control group (n = 40)

                                   n     %      Mean [+ or -] SD

Age (years)                                    37.3 [+ or -] 8.7
    Male                           24
    Female                         16
Body mass index (kg/[m.sup.2])                 21.9 [+ or -] 5.6
Smokers                                 27.5
Heart rate (beats/min)                         73.2 [+ or -] 8.5
Systolic blood pressure (mmHg)                 115.4 [+ or -] 8.3
Diastolic blood pressure (mmHg)                75.1 [+ or -] 6.2
Glucose (mg/dL)                                88.7 [+ or -] 6.9
White blood cells (x [10.sup.3]                 7.8 [+ or -] 1.7
Hemoglobin (g/dL)                              14.2 [+ or -] 1.67
Platelets (x [10.sup.6]/                        8.3 [+ or -] 3.2
Urea (mg/dL)                                   29.2 [+ or -] 9.3
Creatinine (mg/dL)                              0.9 [+ or -] 0.2
Triglyceride (mg/dL)                            130 [+ or -] 33
Total cholesterol (mg/dL)                       179 [+ or -] 34

Characteristic                       P

Age (years)                        0.267
Sex                                0.436
Body mass index (kg/[m.sup.2])     0.423
Smokers                            0.789
Heart rate (beats/min)             0.639
Systolic blood pressure (mmHg)     0.351
Diastolic blood pressure (mmHg)    0.542
Glucose (mg/dL)                    0.784
White blood cells (x [10.sup.3]    0.647
Hemoglobin (g/dL)                  0.703
Platelets (x [10.sup.6]/           0.322
Urea (mg/dL)                       0.715
Creatinine (mg/dL)                 0.725
Triglyceride (mg/dL)               0.741
Total cholesterol (mg/dL)          0.754

AS: Ankylosing spondylitis; SD: Standard deviation.

Table 2. Echocardiographic features of study subjects

Variable                   AS patient group      Control group
                               (n = 42)             (n = 40)

                           Mean [+ or -] SD     Mean [+ or -] SD

Left ventricle ejection   66.3 [+ or -] 5.2    64.3 [+ or -] 6.2
  fraction (%)
Left ventricular          50.2 [+ or -] 5.1    49.3 [+ or -] 4.1
  diameter (mm)
Left ventricle            33.2 [+ or -] 3.5    31.5 [+ or -] 3.6
  end-systolic diameter
Left ventricle mass       98.5 [+ or -] 18.6   94.6 [+ or -] 18.2
  index (gr/[m.sup.2])
Septum thickness (mm)      8.9 [+ or -] 1.2     8.8 [+ or -] 1.1
Posterior wall             8.3 [+ or -] 0.7     8.5 [+ or -] 0.6
  thickness (mm)
E wave (cm/s)             81.2 [+ or -] 17.6   83.1 [+ or -] 23.5
A wave (cm/s)             72.1 [+ or -] 15.5   71.6 [+ or -] 18.3
Left ventricle E/A        1.14 [+ or -] 0.13   1.17 [+ or -] 0.12
Left atrium diameter      39.2 [+ or -] 3.2    33.4 [+ or -] 4.8

Variable                    p

Left ventricle ejection   0.107
  fraction (%)
Left ventricular          0.540
  diameter (mm)
Left ventricle            0.213
  end-systolic diameter
Left ventricle mass       0.113
  index (gr/[m.sup.2])
Septum thickness (mm)     0.432
Posterior wall            0.133
  thickness (mm)
E wave (cm/s)             0.102
A wave (cm/s)             0.180
Left ventricle E/A        0.210
Left atrium diameter      0.012

AS: Ankylosing spondylitis; SD: Standard deviation.

Table 3. Atrial electromechanical coupling, epicardial
fat thickness, and carotid intima-media thickness results
of study subjects

Variable                     AS patient group      Control group
                                 (n = 42)             (n = 40)

                             Mean [+ or -] SD     Mean [+ or -] SD

Atrial electromechanical    68.4 [+ or -] 12.3   63.2 [+ or -] 11.6
  coupling lateral (ms)
Atrial electromechanical    55.2 [+ or -] 10.5   48.6 [+ or -] 5.3
  coupling septal (ms)
Atrial electromechanical    45.6 [+ or -] 8.9    39.2 [+ or -] 5.8
  coupling tricuspid (ms)
Atrial electromechanical    29.5 [+ or -] 5.8    17.9 [+ or -] 5.3
  coupling lateral-
  tricuspid (interatrial)
Atrial electromechanical    18.2 [+ or -] 4.6    11.7 [+ or -] 3.5
  coupling lateral-septum
  (left intraatrial) (ms)
Atrial electromechanical    11.9 [+ or -] 3.2     7.1 [+ or -] 3.2
  coupling septum-
  tricuspid (right
  intraatrial) (ms)
Right carotid intima-       0.51 [+ or -] 0.11   0.43 [+ or -] 0.04
  media thickness (mm)
Left carotid intima-media   0.50 [+ or -] 0.11   0.44 [+ or -] 0.06
  thickness (mm)
Epicardial fat thickness    0.73 [+ or -] 0.15   0.63 [+ or -] 0.07

Variable                      p

Atrial electromechanical     0.05
  coupling lateral (ms)
Atrial electromechanical    0.001
  coupling septal (ms)
Atrial electromechanical    <0.001
  coupling tricuspid (ms)
Atrial electromechanical    <0.001
  coupling lateral-
  tricuspid (interatrial)
Atrial electromechanical    <0.001
  coupling lateral-septum
  (left intraatrial) (ms)
Atrial electromechanical    <0.001
  coupling septum-
  tricuspid (right
  intraatrial) (ms)
Right carotid intima-       <0.001
  media thickness (mm)
Left carotid intima-media   0.008
  thickness (mm)
Epicardial fat thickness    <0.001

AS: Ankylosing spondylitis; SD: Standard deviation.
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Author:Caglar, Sabri Onur; Boyraz, Ismail; Erdem, Fatma; Yazici, Selma; Caglar, Hilal; Koc, Bunyamin; Cagla
Publication:Archives of Rheumatology
Date:Dec 1, 2016
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