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Esophageal pH in GERD.

Some of the patients who have been chronically taking proton pump inhibitors to achieve complete control over the symptoms of gastroesophageal reflux disease continue to have high intraesophageal pH, reported Dr. David Milkes and his associates at Stanford (Calif.) University.

The 24-hour intraesophageal pH did not normalize in 25 of 50 patients treated with proton pump inhibitors (PPIs) for complete control of gastroesophageal reflux disease (GERD). The patients who did not normalize their intraesophageal pH spent a significantly higher percentage of time with a pH measuring lower than 4 than did patients with normalized esophageal acid exposure.

Intragastric and intraesophageal pH were related significantly in patients who did not normalize their intraesophageal pH, which suggested that these patients have an inadequate inhibition of gastric acid (Am. J. Gastroenterol. 99[6]:991-96, 2004).

All of the patients were negative for Helicobacter pylori and had used PPIs for an average of about 5 years.
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Title Annotation:Clinical Capsules
Author:Evans, Jeff
Publication:Internal Medicine News
Article Type:Brief Article
Geographic Code:1USA
Date:Jul 15, 2004
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