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Enzyme structure to help drug design.

Enzyme structure to help drug design

Using an innovative X-ray machine coupled to a computer, agroup of scientists has determined the structure of an enzyme important in the development of anticancer drugs. Because the enzyme, thymidylate synthetase, plays a crucial role in the DNA synthesis of rapidly growing cells, many anticancer agents are designed to block its activity, thereby inhibiting tumor growth. Researchers from the University of California at San Francisco report in the Jan. 23 SCIENCE that their description of the enzyme's precise three-dimensional structure will lead to improved cancer therapy. Presumably, those drugs could be designed to recognize the enzyme and fasten to it more tightly than the current drugs.
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Title Annotation:thymidylate synthetase
Publication:Science News
Date:Feb 7, 1987
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