Printer Friendly

Enzyme structure to help drug design.

Enzyme structure to help drug design

Using an innovative X-ray machine coupled to a computer, agroup of scientists has determined the structure of an enzyme important in the development of anticancer drugs. Because the enzyme, thymidylate synthetase, plays a crucial role in the DNA synthesis of rapidly growing cells, many anticancer agents are designed to block its activity, thereby inhibiting tumor growth. Researchers from the University of California at San Francisco report in the Jan. 23 SCIENCE that their description of the enzyme's precise three-dimensional structure will lead to improved cancer therapy. Presumably, those drugs could be designed to recognize the enzyme and fasten to it more tightly than the current drugs.
COPYRIGHT 1987 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1987, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:thymidylate synthetase
Publication:Science News
Date:Feb 7, 1987
Words:112
Previous Article:C. subspinosus, I presume?
Next Article:Gene defect may cause some cataracts.
Topics:


Related Articles
American forces press service (Oct. 3, 2005): Pace issues guidance to help military 'shape the future'.
City gets option to buy 2 Broadway buildings.
MS pills are making news.
New publications for professionals.
What we are doing about symptoms that can't be measured easily.
New litigation groups certified at Miami convention.
Compounded drugs are dangerous concoctions, critics say.
Drugs just a click away: online pharmacies can make dangerous drugs easy to get, but also can promote better health care. Should we regulate them?
Lethal injection is inhumane, say researchers.
"Intelligent design," Natural Design, and the problem of meaning in the natural world.

Terms of use | Copyright © 2016 Farlex, Inc. | Feedback | For webmasters