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Enzyme catalysis.

U.S. Patent 7,205,373 (April 17, 2007), "Enzyme Catalyzed Organosilicon Esters and Amides," Kurt Friedrich Brandstadt, Thomas Howard Lane, and Richard A. Gross (Dow Corning Corp., Midland, Michigan, USA, and Polytechnic University, Brooklyn, New York, USA).

Organosilicon esters and amides can be synthesized with an acid or base catalyst at high temperatures for long time periods. However, these processes are subject to uncontrolled side reactions, redistribution of monomer sequences, and crosslinking, resulting in broad molecular-weight distributions. Precise structure control is not possible. Brandstadt, Lane, and Gross solve this problem with enzyme catalysts such as hydrolase enzymes. The hydrolase enzymes selectively catalyze the formation of the amide or ester bonds between carboxylic acid, ester, or amide functional groups and the alcohol groups of the organosilicon reactant. The hydrolase enzyme is generally a lipase or protease that can be obtained from bacteria, fungi, or mammals. The enzyme can be in a heterogeneous suspension and can be lyophilized or immobilized.

Roger D. Corneliussen is Professor Emeritus of Materials Engineering, Drexel University, in Philadelphia, Pennsylvania, USA. He is editor of Maro Polymer Alerts and the Maro Polymer website ( He has been active in SPE since 1962 and has served on the board of the Philadelphia Section and as SPE Councilor. For Maro Patent Alerts he reviews all U.S. Patents weekly, makes links to the polymer-related patents, and sends the links daily to subscribers. These patent abstracts are based on the weekly selection process. To sample Maro Patent Alerts, email a request to
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Title Annotation:industry PATENTS
Author:Corneliussen, Roger
Publication:Plastics Engineering
Article Type:Brief article
Geographic Code:1USA
Date:Jul 1, 2007
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