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Enzyme, cancer spread: link confirmed.

Enzyme, cancer spread: Link confirmed

High levels of an estrogen-dependent enzyme in surgically removed breast cancer tissue indicate an increased likelihood of recurrence, researchers report in the Feb. 1 NEW ENGLAND JOURNAL OF MEDICINE. The new work confirms earlier findings by French scientists (SN: 11/18/89, p.325).

Researchers at the University of Texas at San Antonio examined tumors removed from 397 breast cancer patients. They found that high levels of the enzyme cathepsin-D in 199 women whose tumors had not yet metastasized indicated these patients were 2.6 times as likely to develop a recurrence and 3.9 times as likely to die from the spreading cancer, compared with patients having low cathepsin-D levels.
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Title Annotation:cathepsin-D
Publication:Science News
Date:Feb 10, 1990
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