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Engine operating conditions and exhaust toxicity.

The composition of diesel engine exhaust (DEE) varies by engine type and condition, fuel, engine operation, and sexhaust after-treatment. DEE has been shown to increase inflammation, susceptibility to infection, and cardiovascular responses in experimentally exposed rodents and humans. Engines used in these studies have been operated at idle, at different steady-state loads, or on variable-load cycles. However, exposures have often been reported only as the mass concentration of particulate matter (PM), and the effects of different engine loads and resulting differences in DEE composition are unknown. McDonald et al. (p. 1136) assessed the impacts of load-related differences in DEE composition on models of inflammation, susceptibility to infection, and cardiovascular toxicity. Differences in engine load, as well as other operating variables, are important determinants of the type and magnitude of responses to inhaled DEE. PM mass concentration alone is not a sufficient basis for comparing or combining results from studies using DEE generated under different conditions.

* Also see Science Selections, p. A355
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Title Annotation:Research
Publication:Environmental Health Perspectives
Article Type:Brief article
Geographic Code:1USA
Date:Aug 1, 2011
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