Printer Friendly

Energy-based therapy plus oxymetazoline improved erythema.

ENERGY-BASED therapy with adjunctive oxymetazoline was safe and improved facial erythema for patients with moderate to severe facial erythema associated with rosacea, in an open-label, phase 4 study.

The study evaluated energy-based therapy with oxymetazoline cream (1%) in 46 patients with rosacea, who had moderate to severe facial erythema. They were treated with one of four energy-based devices: pulseddye laser Vbeam Perfecta (PDL-Vbeam), pulsed-dye laser Cynergy (PDL-Cynergy), intense pulsed-light therapy (IPL), or potassium titanyl phosphate laser (KTP laser), plus oxymetazoline. On days 3-27 and 3156, oxymetazolinewas applied once daily; energy-based therapy was provided on day 1 and day 29.

The exploratory efficacy endpoint was the clinician erythema assessment (CEA) score from start of therapy measured over a 6-hour period post treatment. Among the 43 patients who completed the study, the CEA score was improved in 39 (90.7%) patients 6 hours post treatment on day 56 and in 30 (68.2%) patients pretreatment, reported Emil A. Tanghetti, MD, of the Center for Dermatology and Laser Surgery in Sacramento, and coauthors. On day 31, "one-grade or greater improvement was observed" in 26 (60.5%) patients before application of oxymetazoline, and in 38 (88.4%) of patients 6 hours post treatment.

Overall, patient satisfaction increased during the study, with 28 (65.1%) of patients reporting they were satisfied or very satisfied with the treatment on day 56.

Among 46 patients who received at least one treatment, 5 (10.9%) had one or more treatment-emergent adverse events; all were considered mild or moderate. Three (6.5%) patients had oxymetazoline-related adverse events and discontinued the study.

The researchers acknowledged that a key limitation of the study was the use of multiple devices, delivered by different providers, which could have caused inconsistency in the results. "Prospective clinical studies assessing the long-term safety and efficacy of combined treatment with oxymetazoline and energy-based therapies are needed," they wrote.

The manuscript was funded by oxymetazoline manufacturer Aclaris. Several authors disclosed being an investigator, consultant, and /or adviser for laser manufacturers. One author was an Aclaris employee.

BY CALEB RANS, PHARMD

FROM LASERS IN SURGERY AND MEDICINE

dermnews@mdedge.com

SOURCE: Tanghetti EA et al. Lasers Surg Med. 2020 May 6. doi: 10.1002/ lsm.23253.

COPYRIGHT 2020 International Medical News Group
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2020 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:ROSACEA
Author:Rans, Caleb
Publication:Dermatology News
Date:Jun 1, 2020
Words:367
Previous Article:Kawasaki disease.
Next Article:When to suspect it and what to do about it.
Topics:

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters