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Endoscopic approach for a laryngeal neoplasm in a dog/Abordagem endoscopica de neoplasia em laringe em um cao.

Laryngeal and tracheal tumors are rare in dogs and cats; thus, there is little information on the incidence, clinical signs, types, diagnosis, treatment and prognosis of these tumors (CLIFFORD & SORENMO, 2004; DUNBAR et al., 2012; MACPHAIL, 2014). One review described 24 cases (13 dogs and 11 cats) spanning a 10-year period in which laryngeal tumors comprised 0.02% of all biopsy and necropsy specimens in dogs, comprising 11 different tumor types (SAIK et al., 1986; DUNBAR et al., 2012). Tumors in this area are a diagnostic challenge but can be biopsied and excised with endoscopic instruments in many cases (WITHROW, 2013). A total laryngectomy with a permanent tracheostomy is usually performed as the conventional treatment for malignant tumors in humans. Although frequently used in humans, this technique is not commonly used in veterinary medicine (SAIK et al., 1986; FOSSUM & ROGERS, 1998). Thus, the goal of this study was to report a successful case of a videosurgical approach to the excision of a laryngeal neoplasm from a dog.

A 13-year-old Boxer bitch weighing 25kg was referred to the veterinary hospital, presenting with severe dyspnea. The owner reported that the patient had exhibited respiratory changes (dyspnea) with a noticeable aggravation over the past three days. In the physical examination the dog was apathetic in an orthopneic position, severely dyspneic and cyanotic.

The patient underwent radiography of the thorax and upper airways, and a mass was observed in the larynx protruding toward the trachea. This mass was located at the laryngeal lumen and was responsible for the respiratory obstruction and consequent dyspnea (Figure 1A). In addition to the imaging exams to establish the correct stage of the tumor, an aspiration biopsy of the submandibular lymph nodes was performed, but no neoplastic cells were observed in these structures.

Subsequently, the use of endoscopy was chosen for diagnosis, and an attempt was made to excise the mass. Intravenous etomidate (1mg [kg.sup.-1]), midazolam (0.5mg [kg.sup.-1]) and lidocaine (1mg [kg.sup.-1]), combined in the same syringe, were used for anesthetic induction. Anesthetic maintenance was performed with isoflurane, initially with a mask because orotracheal intubation was impossible, and then, a tracheostomy was performed, thus stabilizing the cardiorespiratory parameters for the procedure.

During the endoscopic procedure, a 10mm rigid endoscope/ nephroscope 5mm with a working channel, 5-mm atraumatic Babcock forceps, bipolar cutting and bipolar coagulation forceps (LinaTripolPowerBlade[R], WEM & VIVAMED, RibeiraoPreto, SP, Brazil) were used. The instruments were inserted through the mouth, and after reaching the larynx, the mass was observed in the laryngeal lumen, confirming the radiographic findings. The areas where the mass adhered to the laryngeal mucosa were found using the forceps, and a surgical aspirator was necessary to remove the excess mucus and blood covering the field of view. After inspection, bipolar cutting and coagulation of the areas where the mass was attached to the organ's mucosa were performed, followed by the removal of the mass (Figure 1B). Then, bipolar cutting and coagulation of the vestiges of the mass were performed, followed by cleaning of the area with a 0.9% NaCl solution, aspiration of the content and final inspection of the area, which did not present significant bleeding. The tracheostomy was reversed, and the patient was kept under observation until complete anesthetic recovery. Immediately after surgery, the patient showed improvement in breathing pattern and the patient's mucous membranes had a normal color.

The resected tissue, which was 2.0x1.3x1.0cm, was macroscopically analyzed. It had a soft surface when cut, an irregular shape and a whitish-brown color; the tissue was stored in a formaldehyde solution (10%) for subsequent histopathological examination (Figure 1D). The histopathological analysis revealed a malignant neoplasm that was characterized by epithelial cell proliferation, high-grade pleomorphism and numerous mitotic figures and that had hemorrhagic foci, which indicated a poorly differentiated neoplasm with probable epithelial origin, thus suggesting the presence of a carcinoma (Figure 2).

Due to the severe dyspnea, an abdominal ultrasound was performed after the endoscopy when the breathing pattern was normal; however, no alterations suggesting that other organs were affected were observed.

Because it was impossible to perform radiotherapy, adjuvant chemotherapy was indicated; however, due to the owner's decision, chemotherapy was not performed. Approximately 40 days after the endoscopic procedure, the patient presented with hind limb paralysis and severe dyspnea. Thoracic and lumbar spine radiography revealed miliary lung lesions and spinous process irregularity with bone rarefaction of the dorsal compartment of the sixth lumbar vertebra, which suggested pulmonary and lumbar spine metastasis. Euthanasia was performed due to the clinical condition of the patient, but the owner did not authorize the performance of a necropsy to confirm the metastasis.

Although laryngeal carcinomas are common in humans mainly due to habits such as alcohol and tobacco use, there are few reports in the veterinary literature of such neoplasms in dogs. The laryngeal neoplasms reported in dogs were rhabdomyomas, extramedullaryplasmacytomas, chondrosarcomas, carcinomas, fibrosarcomas and mastocytomas (MEUTEN et al., 1985; HAYES et al., 2007; MACPHAIL, 2014). Except for the rhabdomyomas, most of these neoplasms are locally invasive and have a high metastatic potential (WITHROW, 2013).

In the present study, there were no signs of metastasis to the lung at the diagnosis, which was confirmed by radiography. Furthermore, there was no submandibular lymphadenomegaly, and the cytological analysis indicated that there was no neoplastic invasion, although no histopathological examination was performed, which is considered to be the gold standard for lymph node metastasis detection. In humans, 60% of laryngeal carcinomas are localized, 30% exhibit satellite lymph node metastasis, and 10% exhibit distant metastasis (MENDENHALL et al., 2005).

The most appropriate treatment for benign laryngeal tumors is resection of the neoplasm and the submucosa or a partial laryngectomy. Aggressive surgical intervention involves complete laryngectomy with permanent tracheostomy but has been reported only in isolated cases (MACPHAIL, 2014). However, partial and total laryngectomies are associated with several postoperative complications that make their use more difficult. Aspiration pneumonia may occur due to the inappropriate closing of the larynx during swallowing. In addition, intermittent and excessive coughing due to the production of granulation tissue where the tumor was excised, dysphagia, nausea and fistula secondary to wound dehiscence may occur (FOSSUM & ROGERS, 1998; MACPHAIL, 2014).

In contrast, the endoscopic approach allowed the visualization of the lesion in situ with a high magnification of the image (Figure 1B), which facilitated the surgical removal of the mass with videosurgery. The removal was accomplished with minimal manipulation of the affected area and without the need to resect anatomical structures to access the tumor, thus minimizing the postoperative complications, which resulted in a safer and faster recovery for the patient (Figure 1C) (MARTINS et al., 2009; OLIVIERI et al., 2009). Concerns regarding the use of the endoscopic procedure are related to the need of appropriate materials and difficulty to achieve free margins of the neoplasm (OLIVIERI et al., 2009; MENDENHALL et al., 2005; CLIFFORD & SORENMO, 2004).

In veterinary medicine, there are no reports of endoscopic treatments in cases of laryngeal tumors, but it is a resource, together with electrosurgery which has been shown effective for the treatment of this condition. In humans the use of transoral laser surgery performed by laryngoscopy has been developing in recent years. This approach does not follow one of the basic principles of oncologic surgery because the tumor is segmented and then removed in pieces in some cases. However, the cutting part reveals the depth of penetration of the tumor and allows a clear view of the resection margins during surgery (RODRIGO et al., 2011).

The primary clinical symptoms in patients with laryngeal tumors are due to the physical presence of the mass, which obstructs the airway as it grows, or due to the accumulation of secretions in the airway (SAIK et al., 1986). Thus, the immediate improvement of the patient's respiratory distress after the removal of the mass through videosurgery (during the postsurgical period) is explained. In some cases, in addition to the removal of the neoplasm, there is the possibility of performing radiotherapy as a way to locally control the disease when dealing with a radiosensitive tumor (WITHROW, 2013), but this treatment is still difficult to access in Brazil.

In this case, treatment using videosurgery was shown to be efficient and minimally invasive when treating a laryngeal neoplasm, providing an important improvement to the patient in the immediate postsurgical period.

PROTOCOL COMMITTEE OF ETHICS 017022/13.

http://dx.doi.org/ 10.1590/0103-8478cr20131084

Received 08.10.13

Approved 03.14.14

Returned by the author 08.25.14

CR-2013-1084.R1

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Pedro Paulo Maia Teixeira (I,III) Erica Siqueira Souza (I) Paulo Cesar Jark (II) * Leandro Nassar Coutinho (I) Alanna do Socorro Lima da Silva (I) Marcos Vinicius Sicca Guiduce (II) Bruna Piva Maria (II) Paloma Espirito Santo Silva (II) Livia Maria Souza Semolin (II) Marco Augusto Machado Silva (I) IV Wilter Ricardo Russiano Vicente (I) Mirela Tinucci-Costa (II) Andrigo Barboza De Nardi (II)

(I) Departamento de Medicina Veterinaria Preventiva e Reproducao Animal, Universidade Estadual Paulista (UNESP), Jaboticabal, SP, Brasil.

(II) Departamento de Clinica e Cirurgia Veterinaria, UNESP, Via de Acesso Prof. Paulo Donato Castellane s/n, 14884-900, Jaboticabal, SP, Brasil. E-mail: paulocjark@hotmail.com.*Corresponding author.

(III) Departamento de Veterinaria da Universidade Estadual do Centro Oeste do Parana (UNICENTRO), Guarapuava, PR, Brasil.

(IV) Universidade de Passo Fundo (UPF), Passo Fundo, RS, Brasil.
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Title Annotation:clinica y cirugia; texto en ingles
Author:Teixeira, Pedro Paulo Maia; Souza, Erica Siqueira; Jark, Paulo Cesar; Coutinho, Leandro Nassar; da S
Publication:Ciencia Rural
Date:Jan 1, 2015
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