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Efficacy of Sodium Chlorite plus Zinc Gluconate on Volatile Sulfur Compound Halitosis: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Problem Statement: There are no published clinical research data on the efficacy of sodium chlorite plus zinc gluconate, whether in the form of a mouthrinse or in any other composition, on halitosis.

Purpose: This quantitative study aimed to assess the efficacy of sodium chlorite plus zinc gluconate (SC+ZG) mouthrinse in adults with halitosis.

Methods: This randomized, double-blind, placebo-controlled study used the Yaegaki et al. standardized oral malodor clinical research protocol. The study was approved by the MCPHS University IRB and open to adults 18 years and older, who complained of or had been told they had halitosis. Seventeen of 22 recruited subjects followed pre-testing preparation. On test day, baseline measurements of hydrogen sulfide (H,S), methylmercaptan (MM), and dimethyl sulfide (DMS) were obtained using an OralChroma[R] CHM-2 gas chromatograph. Subjects were randomized to SC+ZG or placebo rinses. Supervised subjects rinsed with 15 mL of SC+ZG or placebo for 60 seconds and subsequently gargled with a second dose of the assigned mouthrinse for 30 seconds. Subjects were not permitted to eat or drink for 3 hours after the rinsing and gargling regimen, at which time measurements were repeated.

Results: Using analysis of variance (ANOVA) for continuous variables and Fisher's Exact Test for categorical variables, there were no statistically significant differences in demographics between the groups. Differences in effect estimates between treatment arms were found in mean gas concentrations of 1LS and MM from baseline to post-rinse. Mean [H.sub.2]S gas concentration decreased by 16.4 ppb (95% CI -54.9, 22.1) in the treatment group, but only by 2.9 ppb (95% CI -11.7, 5.9) in the placebo group and by 28.4 ppb (95% CI -54.8, -1.9) and 11.2 ppb (95% CI -31.8, 9.3) for MM gas in the treatment and placebo arms, respectively. Results were not inferentially statistically significant, for any of the VSCs, likely due to the study being underpowered.

Conclusions: Study findings did not support evidence of efficacy of SC+ZG on halitosis.

*Susan M. Badanjak, MSDH, RDH

Linda D. Boyd, RD, EdD, RDH

Kristeen R. Perry, MSDH, RDH

Lisa M. LaSpina, MS, RDH

Andrew T. Rothman, MS, EIT

Lisa Byrne, BS, RDH

Forsyth School of Dental Hygiene, MCPHS University, Boston, MA, United States

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Title Annotation:Dental Hygiene Practice
Author:Badanjak, Susan M.; Boyd, Linda D.; Perry, Kristeen R.; LaSpina, Lisa M.; Rothman, Andrew T.; Byrne,
Article Type:Report
Date:Apr 1, 2018
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