Effects of meloxicam on hematologic and plasma biochemical analysis variables and results of histologic examination of tissue specimens of Japanese quail (Coturnix japonica).
Objective--To determine the effects of meloxicam on values of hematologic and plasma biochemical analysis variables and results of histologic examination of tissue specimens of Japanese quail (Coturnix japonica). Animals--Thirty adult Japanese quail. Procedures--Fifteen quail underwent laparoscopic examination of the left kidneys, and 15 quail underwent laparoscopic examination and biopsy of the left kidney. Quail in each of these groups received meloxicam (2.0 mg/kg, IM, ql2h; n = 10) or a saline solution (0.9% NaC1) solution (0.05 mL, IM, ql2h; control birds; 5) for 14 days. A complete blood cell count and plasma biochemical analyses were performed at the start of the study and within 3 hours after the last treatment. The birds were euthanatized, and necropsies were performed. Results--No adverse effects of treatments were observed, and no significant changes in values of hematologic variables were detected during the study. Plasma uric acid concentrations and creatine kinase or aspartate aminotransferase activities were significantly different before versus after treatment for some groups of birds. Gross lesions identified during necropsy included lesions at renal biopsy sites and adjacent air sacs (attributed to the biopsy procedure) and pectoral muscle hemorrhage and discoloration (at sites of injection). Substantial histopathologic lesions were limited to pectoral muscle necrosis, and severity was greater for meloxicam-treated versus control birds. Conclusions and Clinical Relevance--Meloxicam (2.0 mg/kg, IM, ql2h for 14 days) did not cause substantial alterations in function of or histopathologic findings for the kidneys of Japanese quail but did induce muscle necrosis; repeated intramuscular administration of meloxicam to quail may be contraindicated.
Am J Vet Res. 2012;73:1720-1727.
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|Author:||Sinclair, K.M.; Church, M.E.; Farver, T.B.|
|Publication:||Journal of Avian Medicine and Surgery|
|Date:||Mar 1, 2013|
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