Effects of Ultrasound-Guided Thoracic Paravertebral Block on Postoperative Pain in Children Undergoing Percutaneous Nephrolithotomy.
Percutaneous nephrolithotomy (PNL) is widely used in the treatment of renal calculi. However, the dilatation of surrounding tissues due to the nephrostomy tube placement can cause postoperative pain (1). Various analgesic techniques, such as systemic analgesia and central and peripheral nerve blocks (intercostal and paravertebral blocks) are used to provide postoperative analgesia for PNL in adult patients (2-4).
Currently, the use of peripheral nerve blocks applied with landmark-based techniques, nerve stimulators or ultrasound guidance helps to improve postoperative pain management in children (5). In the literature, several studies have indicated that paravertebral block (PVB) provides effective analgesia for various surgical procedures in paediatric populations (6-9). The mechanism of PVB is the penetration of local anaesthetic into the intercostal and sympathetic nerves within the paravertebral space (10).
Paracetamol is a non-opioid analgesic used widely for postoperative pain in children. It also has an antipyretic effect. Endogenous opioid, serotonergic and nitric oxide pathways are thought to contribute to the mechanism of its analgesic action. It can be administered via the intravenous (IV), rectal or oral route. It has been reported that the maximum plasma concentration is achieved faster with IV paracetamol than with oral and rectal routes. The analgesic effect of paracetamol begins within 15 min following intravenous administration, and it lasts 4-6 hours (11).
For adult patients, ultrasound-guided PVB is widely performed in many surgical procedures, including breast surgery and thoracotomy (12, 13). However, there is a limited number of studies concerning ultrasound-guided thoracic PVB in children (14-16). Thus, the primary aim of our study was to compare the effects of ultrasound-guided thoracic PVB and intravenous (IV) paracetamol on postoperative analgesia based on pain scores in children undergoing PNL surgery. The secondary aim was to evaluate parental satisfaction and requirements for supplemental analgesia in children.
After obtaining Cukurova University Ethics Committee (Approval no. 20/8-2013) approval and written informed parental consent, 40 children aged 1-5 years, with an American Society of Anesthesiologists (ASA) physical status I-II, who were scheduled for elective PNL, were included in this study. The exclusion criteria were parental refusal, spine deformities, cutaneous infection, bleeding diathesis, allergy to drugs used in the study, or an ASA physical status of III-IV.
Patients were given no premedication. All children were monitored with electrocardiogram and pulse oximetry, and their blood pressure was measured non-invasively after arriving to the operating room with their parents. After the induction of anaesthesia with 2%-8% sevoflurane, venous access was established, and all patients received 5-10 mL [kg.sup.-1] [h.sup.-1] Ringer's lactate solution. After muscle relaxation was ensured with rocuronium bromide (0.5 mg [kg.sup.-1], IV), the patients were intubated. Anaesthesia maintenance was provided with 1%-2% sevoflurane and a mixture of 50% nitrous oxide and oxygen. The sevoflurane concentration was adjusted to maintain haemodynamic parameters within [+ or -]25% of preoperative baseline values. If needed, fentanyl (1 [micro]g [kg.sup.-1]) was used for intraoperative analgesia. The intraoperative inspired sevoflurane concentration, systolic and diastolic blood pressures (SBP and DBP), heart rate (HR) and peripheral oxygen saturation (Sp[O.sub.2]) were recorded at 5, 10, 15, 30, 45, 60, 90 and 120th minutes.
Using a computer-generated list, the patients were randomly allocated into two groups to receive either ultrasound-guided PVB (n=20, Group PVB) or IV paracetamol (n=20, Group P). Randomisation was done before the surgery. The patients (or their parents) and the anaesthesiologist who performed the PVB were aware of the allocated arm, but the outcome assessors were kept blinded to the allocation. All PVBs were performed by the same anaesthesiologist experienced in ultrasound-guided nerve blocks in children. After intubation, all patients were placed in the prone position. A 15 MHz linear ultrasound probe (MyLabFive ESAOTE, Maastricht, Netherlands) was placed in the vertical-caudal plane, and the spinous process, transverse process and paravertebral space at each vertebral level from T10 to L1 were identified from midline to lateral. After the skin was cleansed with 10% povidone-iodine solution and draped in a sterile manner, a 5 cm, 22-G insulated needle (Stimuplex; B. Braun Medical Inc, Bethlehem, PA, USA) was inserted. The needle was advanced from the sagittal direction using the in-plane technique. After entering the costotransverse ligament and obtaining a negative aspiration test, a one-third dose of 0.5 mL [kg.sup.-1] of bupivacaine 0.5 % was injected at each dermatome level. Appropriate spread of local anaesthetic (LA) was confirmed with the anterior movement of the pleura in the paravertebral space. The patients in Group P were administered paracetamol (15 mg [kg.sup.-1], IV) after being placed in the prone position. At the end of PNL, a nephrostomy drainage tube was placed in each patient.
Anaesthesia was discontinued after moving into the supine position at the end of surgery. Neuromuscular blockage was reversed with 15 [micro]g [kg.sup.-1] of IV neostigmine and 50 [micro]g [kg.sup.-1] of IV atropine. All patients were extubated after adequate spontaneous breathing, and then they were transferred to the postoperative recovery room.
Postoperative pain was evaluated with the Face, Legs, Activity, Cry and Consolability (FLACC) scale. The FLACC scale is an observational scoring system used to evaluate postoperative pain of infants and young children aged between 2 months and 7 years. Each parameter is scored between 0 to 2, and the total score ranges from 0 (no pain) to 10 (maximum pain) (17). If the FLACC score was higher than 4, patients in both groups were administered supplemental tramadol (1 mg [kg.sup.-1], IV). FLACC scores, rescue analgesics, SBP, DBP, HR, Sp[O.sub.2] and side effects of hypotension, bradycardia, respiratory problems, nausea or vomiting, and local anaesthetic systemic toxicity (LAST) were recorded postoperatively at 5, 10, 15 and 30 minutes and 1, 2, 4, 6 and 12 hours. Additionally, parental satisfaction was evaluated after the surgery, using a 3-point scale (excellent, good or unsatisfied). Postoperative assessments of the patients' pain and parental satisfaction were performed by an anaesthesiologist 12 hours after the surgery.
The pain level was the primary outcome, while the secondary outcome measures were additional analgesic requirements and parental satisfaction in the postoperative period.
The sample size was estimated as a minimum of 19 subjects for each study group to find a 30% difference in FLACC scores between the groups based on a previous study (9), at a significance level of 5% and a power of 95%. A statistical analysis was performed using the IBM Statistical Packages for the Social Sciences version 22.0 statistical software package (IBM SPSS Corp.; Armonk, NY, USA). Data were reported as the mean[+ or -]standard deviation or number (%). The chi-squared test was used to compare categorical measurements between the two groups. The Mann-Whitney U test was used for anaesthesia and surgery time and for the FLACC scores. The statistical significance level was set at 0.05 for all tests.
The demographic data, anaesthesia and surgery time were similar in both groups (Table 1). FLACC scores were significantly lower in Group PVB than in Group P (p=0.001) (Table 2). There were no postoperative analgesic requirements in Group PVB. However, 20 patients in Group P required supplemental analgesia in the postoperative period; 19 received tramadol in the first 10 min and 1 received tramadol in the first hour. All patients in Group PVB had FLACC scores <4 during the study period. Patients with FLACC scores of <4 in Group P are shown in Table 3. Parental satisfaction scores were higher in Group PVB than in Group P (Table 4).
No significant difference was found between the two groups in intra- and postoperative haemodynamic parameters. Intraoperative inspired sevoflurane concentrations were significantly lower in Group PVB than in Group P, except at the 5-min measurement (p=0.001).
No side effects, such as hypotension, bradycardia, respiratory problems, nausea or vomiting and LAST were observed in any of the patients.
The results of this study showed that ultrasound-guided PVB is effective against postoperative pain in children undergoing PNL surgery, and it reduced the additional analgesic requirements.
Although tubeless PNL is currently widely performed for renal calculi, a nephrostomy drainage tube was used based on the preference of the surgical team. However, nephrostomy drainage tube has some disadvantages, such as leading to a prolonged hospital stay and increased analgesia requirements (18, 19). We found that ultrasound-guided PVB provided sufficient pain relief for 12 hours after the PNL surgery. Most of the studies in the literature are related to PVB applied using landmarks or nerve stimulators, and these studies support our finding that PVB effectively reduces postoperative pain in children (6-8). On the other hand, the number of studies related to ultrasound-guided PVB in children is limited (14, 15, 20). Qi et al. (14) reported that ultrasound-guided bilateral PVB reduces postoperative pain scores in children undergoing the Nuss procedure. In two other studies, a catheter was inserted within the paravertebral space, and then LA infusion with 0.2% ropivacaine was performed (15, 20). These studies demonstrated that ultrasound-guided PVB provided satisfactory pain control in the postoperative period. For clinicians, the use of ultrasound for paravertebral block will be helpful for the real-time visualisation of neurovascular structures, reduced LA dosages and prevention of serious complications (21, 22).
In our study, none of the children who underwent ultrasound-guided PVB needed any additional analgesia during the postoperative 12-hour period. In a series of 4 cases related to the inguinal region surgery reported by Eck et al. (23), patients with PVB did not need additional opioids during the first 24 hours postoperatively. Similar studies have shown that PVB, which can be applied via landmarks or nerve stimulators, decreases the use of supplemental analgesia when compared to other methods, such as ilio-inguinal, epidural, or caudal blocks (6-8, 24, 25). Although IV paracetamol is used for postoperative pain control in children, the present study indicated that ultrasound-guided PVB is superior for postoperative analgesia compared to IV paracetamol (11). Furthermore, in the present study, the children in Group P had the FLACC scores <4 in the postoperative period. This can be explained by the analgesic efficiency of tramadol used for supplemental analgesia (26). Additionally, our study showed that ultrasound-guided PVB provided satisfactory analgesic management according to the parents.
PVB can be performed using single- or multiple-injection techniques. The radiographic and sensorial distributions of multiple injections are more comprehensive and secure than single injections, which may indicate greater efficacy in neural tissues (27). However, previous studies have claimed that the multiple-injection technique in PVB may increase the risk of possible complications, including vascular injury, pneumothorax, pleural puncture haematoma, pain at the injection site and epidural/intrathecal spread (8, 9, 24). The single-injection technique has a lower incidence of complications due to less exposure to needle punctures (28). Nevertheless, Berta et al. (6) stated that the vascular puncture rate was 8.3% with the single-injection technique. On the other hand, a study on the multiple-injection technique reported that local tenderness at the injection points was experienced in only 3 patients, with no other complications (24). We did not observe any complications with the multiple-injection technique. In accordance with our study, Qi et al. (14) showed that despite the use of bilateral PVBs, there were no complications. These results support the use of ultrasound in PVB to allow visualisation of adjacent structures, thus reducing complications (21). Additionally, PVB leads to less postoperative nausea, vomiting and hypotension compared to other regional techniques (29). None of these complications occurred in any of our patients.
Although ultrasound-guided peripheral nerve block in children reduces the dosage of LA agents, there is a limited number of studies related to optimal dosage regimens (30, 31). In the literature, it is recommended not to exceed the maximum dose of bupivacaine (2.5 mg [kg.sup.-1]) due to possible LAST (32). Ponde et al. (33) stated that bupivacaine 0.5 % at dose of 0.5 mL [kg.sup.-1] was successfully applied in ultrasound-guided infraclavicular brachial nerve block in children. Similarly, bupivacaine 0.25% (1 mL [kg.sup.-1]) was used in caudal block (34-36). A study on caudal block in children undergoing surgery for congenital pyloric stenosis was reported by Moyao-Garcia et al. (37), who reported that the frequency of major complications was low for caudal block with bupivacaine 0.25% (1.6 mL [kg.sup.-1]). Similarly, we achieved effective postoperative analgesia with 0.5 mL [kg.sup.-1] of bupivacaine 0.5%, and no complications occurred based on the LA dose.
A limitation of this study was that there was only a 12-hour follow-up period after the surgery due to a lack of staff for observation. Another limitation of the study was the absence of a sham block technique, so the study did not include a control group. In addition, although our study demonstrated that ultrasound-guided PVB reduced the inspired sevoflurane concentration, we did not measure the amount of sevoflurane consumption. Nevertheless, our findings may provide a positive contribution for children, as exposure to anaesthesia in early childhood is associated with adverse neurodevelopmental outcomes (38).
Ultrasound-guided thoracic PVB provides more effective postoperative analgesia compared to IV paracetamol, without any side effects, in children undergoing PNL surgery.
Ethics Committee Approval: Ethics committee approval was received for this study from the ethics committee of Cukurova University School of Medicine (Approval no. 20/8-2013).
Informed Consent: Verbal and written informed consent was obtained from all parents.
Peer-review: Externally peer-reviewed.
Author Contributions: Concept--G.A.; Design--G.A., Z.H.; Supervision--D.O.; Funding--G.A.; Materials--G.A., Z.H.; Data Collection and/or Processing--G.A.; Analysis and/or interpretation--E.G.; Literature Review--G.A., E.G.; Writer--G.A., Z.H.; Critical Review--D.O.; Other--G.A.
Conflict of Interest: The authors have no conflicts of interest to declare.
Financial Disclosure: Funding was provided by the Scientific Research Projects Coordination Unit of Cukurova University.
(1.) Pietrow PK, Auge BK, Lallas CD, Santa-Cruz RW, Newman GE, Albala DM, et al. Pain after percutaneous nephrolithotomy: impact of nephrostomy tube size. J Endourol 2003; 17: 411-4. [CrossRef]
(2.) Ozkan D, Akkaya T, Karakoyunlu N, Arik E, Ergil J, Koc Z, et al. Effect of ultrasound-guided intercostal nerve block on postoperative pain after percutaneous nephrolithotomy. Anaesthesist 2013; 62: 988-94. [CrossRef]
(3.) Aravantinos E, Kalogeras N, Stamatiou G, Theodorou E, Moutzouris G, Karatzas A, et al. Percutaneous nephrolithotomy under a multimodal analgesia regime. J Endourol 2009; 23: 853-6. [CrossRef]
(4.) Ak K, Gursoy S, Duger C, Isbir AC, Kaygusuz K, Ozdemir Kol I, et al. Thoracic paravertebral block for postoperative pain management in percutaneous nephrolithotomy patients: a randomized controlled clinical trial. Med Princ Pract 2012; 22: 229-33. [CrossRef]
(5.) Bhalla T, Sawardekar A, Dewhirst E, Jagannathan N, Tobias JD. Ultrasound-guided trunk and core blocks in infants and children. J Anesth 2013; 27: 109-23. [CrossRef]
(6.) Berta E, Spanhel J, Smakal O, Smolka V, Gabrhelik T, Lonnqvist PA. Single injection paravertebral block for renal surgery in children. Paediatr Anaesth 2008; 18: 593-7. [CrossRef]
(7.) Tug R, Ozcengiz D, Gunes Y Single level paravertebral versus caudal block in paediatric inguinal surgery. Anaesth Intensive Care 2011; 39: 909-13. [CrossRef]
(8.) Splinter WM, Thomson ME. Somatic paravertebral block decreases opioid requirements in children undergoing appendectomy. Can J Anaesth 2010; 57: 206-10. [CrossRef]
(9.) Naja Z, Lonnqvist PA. Somatic paravertebral nerve blockade. Incidence of failed block and complications. Anaesthesia 2001; 56: 1184-8. [CrossRef]
(10.) Richardson J, Lonnqvist PA, Naja Z. Bilateral thoracic paravertebral block: potential and practice. Br J Anaesth 2011; 106: 164-71. [CrossRef]
(11.) Shastri N. Intravenous acetaminophen use in pediatrics. Pediatr Emer Care 2015; 31: 444-8. [CrossRef]
(12.) Kasimahanti R, Arora S, Bhatia N, Singh G. Ultrasound-guided single- vs double-level thoracic paravertebral block for postoperative analgesia in total mastectomy with axillary clearance. J Clin Anesth 2016; 33: 414-21. [CrossRef]
(13.) Kus A, Gurkan Y, Arslan ZI, Akgul AG, Aksu C, Toker K, et al. Our ultrasound-guided paravertebral block experiences in thoracic surgery. Agri 2015; 27: 139.
(14.) Qi J, Du B, Gurnaney H, Lu P, Zuo Y A prospective randomized observer-blinded study to assess postoperative analgesia provided by an ultrasound-guided bilateral thoracic paravertebral block for children undergoing the Nuss procedure. Reg Anesth Pain Med 2014; 39: 208-13. [CrossRef]
(15.) Boretsky K, Visoiu M, Bigeleisen P. Ultrasound guided approach to the paravertebral space for catheter insertion in infants and children. Paediatr Anaesth 2013; 23: 1193-8. [CrossRef]
(16.) Chalam KS, Patnaik SS, Sunil C, Bansal T. Comparative study of ultrasound-guided paravertebral block with ropivacaine versus bupivacaine for post-operative pain relief in children undergoing thoracotomy for patent ductus arteriosus ligation surgery. Indian J Anaesth 2015; 59: 493-8. [CrossRef]
(17.) Crellin DJ, Harrison D, Santamaria N, Babl FE. Systematic review of the Face, Legs, Activity, Cry and Consolability scale for assessing pain in infants and children: is it reliable, valid, and feasible for use? Pain 2015; 156: 2132-51.
(18.) de Cogain MR, Krambeck AE. Advances in tubeless percutaneous nephrolithotomy and patient selection: an update. Curr Urol Rep 2013; 14: 130-7. [CrossRef]
(19.) Ozturk A, Guven S, Kilinc M, Topbas E, Piskin M, Arslan M. Totally tubeless percutaneous nephrolithotomy: is it safe and effective in preschool children? J Endourol 2010; 24: 1935-9.
(20.) Visoiu M, Yang C. Ultrasound-guided bilateral paravertebral continuous nerve blocks for a mildly coagulopathic patient undergoing exploratory laparotomy for bowel resection. Paediatr Anaesth 2011; 21: 459-62. [CrossRef]
(21.) Lonnqvist PA. Is ultrasound guidance mandatory when performing paediatric regional anaesthesia? Curr Opin Anaesthesiol 2010; 23: 337-41.
(22.) Krediet AC, Moayeri N, van Geffen GJ, Bruhn J, Renes S, Bigeleisen PE, et al. Different Approaches to Ultrasound-guided Thoracic Paravertebral Block: An Illustrated Review. Anesthesiolgy 2015; 123: 459-74. [CrossRef]
(23.) Eck JB, Cantos-Gustafsson A, Ross AK, Lonnqvist PA. What's New in Pediatric Paravertebral Analgesia. Tech Reg Anesth and Pain Manage 2002; 6: 131-5. [CrossRef]
(24.) Naja ZM, Raf M, El Rajab M, Daoud N, Ziade FM, Al Tannir MA, et al. A comparison of nerve stimulator guided paravertebral block and ilio-inguinal nerve block for analgesia after inguinal herniorrhaphy in children. Anaesthesia 2006; 61: 1064-8. [CrossRef]
(25.) Lonnqvist PA, Olsson GL. Paravertebral vs epidural block in children. Effects on postoperative morphine requirement after renal surgery. Acta Anaesthesiol Scand 1994; 38: 346-9. [CrossRef]
(26.) Schnabel A, Reichl SU, Meyer-Friebem C, Zahn PK, Pogatzki-Zahn E. Tramadol for postoperative pain treatment in children. Cochrane Database Syst Rev. 2015; CD009574.
(27.) Naja ZM, El-Rajab M, Al-Tannir MA, Ziade FM, Tayara K, Younes F et al. Thoracic paravertebral block: influence of the number of injections. Reg Anesth Pain Med 2006; 31: 196-201. [CrossRef]
(28.) Kaya FN, Turker G, Mogol EB, Bayraktar S. Thoracic para-vertebral block for video assisted thoracoscopic surgery: single injection versus multiple injections. J Cardiothorac Vasc Anesth 2012; 26: 90-4. [CrossRef]
(29.) Mata-Gomez J, Guerrero-Dominguez R, Garcia-Santigosa M, Ontanilla A. Ultrasound-guided paravertebral block for pyloromyotomy in 3 neonates with congenital hypertrophic pyloric stenosis. Braz J Anesthesiol (English Edition) 2015; 65: 302-5. [CrossRef]
(30.) Sola C, Menace C, Rochette A, Raux O, Bringuier S, Molinari N, et al. Ultrasound-guided tranversus abdominis plane block for herniorrhaphy in children: what is the optimal dose of levobupivacaine? Eur J Anaesthesiol 2014; 31: 327-32.
(31.) Willschke H, Bosenberg A, Marhofer P, Johnston S, Kettner S, Eichenberger U, et al. Ultrasonographic-guided ilioinguinal/iliohypogastric nerve block in pediatric anesthesia: what is the optimal volume? Anesth Analg 2006; 102: 1680-4.
(32.) Johr M. Regional anaesthesia in neonates, infants and children: an educational review. Eur J Anaesthesiol 2015; 32: 289-97. [CrossRef]
(33.) Ponde VC, Diwan S. Does ultrasound guidance improve the success rate of infraclavicular brachial plexus block when compared with nerve stimulation in children with radial club hands? Anesth Analg 2009; 108: 1967-70.
(34.) Fares KM, Othman AH, Alieldin NH. Efficacy and safety of dexmedetomidine added to caudal bupivacaine in pediatric major abdominal cancer surgery. Pain Physician 2014; 17: 393-400.
(35.) Naguib M, Sharif AMY, Seraj M, El Gammal M, Dawlatly AA. Ketamine for caudal analgesia in children: comparison with caudal bupivacaine. Br J Anaesth 1991; 67: 559-64. [CrossRef]
(36.) El-Hennawy AM, Abd-Elwahab AM, Abd-Elmaksoud AM, El-Ozairy HS, Boulis SR. Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children. Br J Anaesth 2009; 103: 268-74. [CrossRef]
(37.) Moyao-Garcia D, Garza-Leyva M, Velazquez-Armenta EY, Nava-Ocampo AA. Caudal block with 4 mg.[kg.sup.-1] (1.6 ml.[kg.sup.-1]) of bupivacaine 0.25% in children undergoing surgical correction of congenital pyloric stenosis. Pediatr Anesth 2002; 12: 404-10. [CrossRef]
(38.) Loepke AW, Soriano SG. An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg 2008; 106: 1681-707. [CrossRef]
Gulsah Akinci (1) [iD], Zehra Hatipoglu (2) [iD], Ersel Gulec (2) [iD], Dilek Ozcengiz (2) [iD]
(1) Clinic of Anesthesiology and Reanimation, 25 December State Hospital, Gaziantep, Turkey (2) Department of Anesthesiology and Reanimation, Cukurova University School of Medicine, Adana, Turkey
Cite this article as: Akinci G, Hatipoglu Z, Gulec E, Ozcengiz D. Effects of Ultrasound-Guided Thoracic Paravertebral Block on Postoperative Pain in Children Undergoing Percutaneous Nephrolithotomy. Turk J Anaesthesiol Reanm 2019; 47(4): 295-300
This study was presented as poster in the meeting of Asian Society of Peadiatric Anaesthesiologists (8-10 May 2014/Istanbul, Turkey).
Corresponding Author: Zehra Hatipoglu E-mail: firstname.lastname@example.org
Received: 28.08.2018 Accepted: 26.10.2018
Available Online Date: 21.02.2019
Table 1. Demographic data of the groups Group PVB Group P p (n=20) (n=20) Age (years) 2.77[+ or -]1.24 3.30[+ or -]1.40 0.217 Height (cm) 100.15[+ or -]14.75 106.90[+ or -]16.45 0.180 Weight (kg) 12.10[+ or -]2.35 13.37[+ or -]2.82 0.129 Surgery time (min) 58.65[+ or -]18.97 61.15[+ or -]18.99 0.745 Anaesthesia time 66.75[+ or -]19.28 64.25[+ or -]19.62 0.501 (min) Data are presented as the mean[+ or -]standard deviation Table 2. FLACC scores Time Group PVB Group P p (n=20) (n=20) 5 min 1.25[+ or -]1.48 (*) 6.05[+ or -]1.60 0.001 10 min 0.80[+ or -]1.32 (*) 5.65[+ or -]1.72 0.001 15 min 0.35[+ or -]0.93 (*) 4.25[+ or -]1.33 0.001 30 min 0.05[+ or -]0.22 (*) 3.95[+ or -]1.05 0.001 60 min 0.05[+ or -]0.22 (*) 2.50[+ or -]1.90 0.001 2 h 0.05[+ or -]0.22 (*) 1.80[+ or -]2.11 0.001 4 h 0.05[+ or -]0.22 (*) 1.00[+ or -]1.65 0.034 6 h 0.05[+ or -]0.22 (*) 0.85[+ or -]1.38 0.015 12 h 0.05[+ or -]0.22 (*) 0.60[+ or -]1.09 0.034 Data are presented as the mean[+ or -]standard deviation. (*) p<0.05, compared with Group P. FLACC: face, legs, activity, cry and consolability Table 3. The number of patients with FLACC Scores <4 Group PVB Group P (n=20) (n=20) 10 min 20 (100%) 1 (5%) 15 min 20 (100%) 6 (30%) 30 min 20 (100%) 8 (40%) 60 min 20 (100%) 13 (65%) 2 h 20 (100%) 15 (75%) 4 h 20 (100%) 19 (95%) 6 h 20 (100%) 19 (95%) 12 h 20 (100%) 20 (100%) Data are presented as the number and percentage. FLACC: face, legs, activity, cry and consolability Table 4. Parental satisfaction scores Group PVB Group P Total p (n=20) (n=20) (n=40) Excellent 2 (10%) 0 (0%) 2 (5.0%) 0.001 Good 18 (90.0%) 4 (20.0%) 22 (55.0%) Unsatisfied 0 (0%) 16 (80.0%) 16 (40.0%) Data are presented as the number and percentage (%) of patients
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|Title Annotation:||Original Article Paediatric Anaesthesia|
|Author:||Akinci, Gulsah; Hatipoglu, Zehra; Gulec, Ersel; Ozcengiz, Dilek|
|Publication:||Turkish Journal of Anaesthesiology and Reanimation|
|Date:||Aug 1, 2019|
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