Printer Friendly

Effect of micro-environment on electro chemistry of cytochrome c. (Withdrawn).

Scientists studying the properties of biologically active molecules often seek to reduce a system to its least common denominator by fixing experimental conditions such as pH, ionic strength, and temperature to values which may or may not reflect in vivo conditions. While providing a simplified experimental system for understanding biochemical properties, this approach may underestimate the behavior under physiological conditions. The non-specific interactions (e. g. spatial crowding) of analytes and neutral solutes has been shown to induce changes in equilibrium and rate constants of up to one order of magnitude. The impact of this macromolecular crowding on the electrochemical behavior of native cytochrome c and a macromolecule-induced partially folded form of cytochrome c has been studied using cyclic voltammetry. Preliminary results suggest changes in protein conformation which are not apparent using spectroscopic methods.
Christopher Stoudemayer, Jack Goldsmith
Department of Chemistry, University of South Carolina
COPYRIGHT 2003 South Carolina Academy of Science
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2003 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Author:Stoudemayer, Christopher; Goldsmith, Jack
Publication:Bulletin of the South Carolina Academy of Science
Article Type:Brief Article
Geographic Code:1U5SC
Date:Jan 1, 2003
Previous Article:Design and cloning of an anti-HIV-1 Tat hammerhead ribozyme. (Withdrawn).
Next Article:Radiative corrections for neutrino-nucleus reactions. (Withdrawn).

Related Articles
Micro-Emulsions and Emulsions in Foods.
Particle Concentrations in Urban Microenvironments.
Effect of micro-environment on electro chemistry of ctyochrome c.
The power in grapefruit. .
Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse. (Article).
Nanotechnology applications to telecommunications and networking.
Micro and nanoengineering of the cell microenvironment; technologies and applications.
Antitargets; prediction and prevention of drug side effects.

Terms of use | Privacy policy | Copyright © 2022 Farlex, Inc. | Feedback | For webmasters |