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Effect of carnosine on Drosophila melanogaster life span.

A positive dose-dependent effect of carnosine (beta-alanyl-L-histidine) on the life span of male Drosophila melanogaster flies was shown. The mean life span of male flies receiving 200 mg/liter carnosine approached that of females. At the same time carnosine had no effect on the life span of female flies. This positive effect of carnosine probably reflects its protective action against age-related accumulation of free radicals and did not depend on carnosine metabolism in the body. Addition of 200 mg/liter histidine and beta-alanine (separately or in combination) had no effect on the mean life span of flies.

Bull Exp Biol Med. 2002 Jun;133(6):559-61

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Title Annotation:Carnosine
Publication:Life Extension
Article Type:Brief article
Geographic Code:1USA
Date:Jun 1, 2012
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