Effect of Thymol on the spontaneous contractile activity of the smooth muscles.
Effects of Thymol on the spontaneous contractile activity (SCA) have been found in in vitro experiments with circular smooth-muscle strips (SMAs) from guinea pig stomach and vena portae. Thymol was found to possess an agonistic effect on the alpha (1)-, alpha(2)-and beta-adrenergic receptors. Its spasmolytic effect is registered at doses higher than 10(-6)M. Thymol in a dose of 10(-4)M inhibits 100% the SCA of the SMAs and reduces the excitatory effect of 10(-5)M ACH to 35%. It is assumed that Thymol has an analgesic effect through its action on the alpha(2)-adrenergic receptors of the nerve cells. By influencing the betaadrenergic receptors in the adipose cells, it is possible to induce increased synthesis of fatty acids and glycerol, which is a prerequisite for increased heat release.
Phytomedicine. 2007 Jan;14(1):65-9
|Printer friendly Cite/link Email Feedback|
|Title Annotation:||Healing Cream|
|Article Type:||Brief article|
|Date:||Sep 1, 2010|
|Previous Article:||Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB.|
|Next Article:||Anti-inflammatory activity of thymol: Inhibitory effect on the release of human neutrophil elastase.|