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Gene Logic Inc. (Nasdaq: GLGC), Gaithersburg, Md., a provider of genomic information, has launched the GeneExpress 2000 database suite, the next generation of the company's GeneExpress gene expression database product. The GeneExpress 2000 database is a massive reference set of gene expression information across a broad range of normal and diseased human tissues, experimental animals and disease models and cell lines. The GeneExpress 2000 replaces the first generation of the GeneExpress software, first released in November 1999, and is currently in the process of being deployed to all current commercial users of the GeneExpress database.

GeneExpress 2000 is delivered on a data management platform that includes a comprehensive gene expression data warehouse back-end, an advanced gene expression analysis engine, and a novel user interface. The GeneExpress 2000 data warehouse integrates gene expression data generated using a variety of platforms (Affymetrix, Inc.'s human, mouse and rat GeneChip(R) microarrays, Gene Logic's proprietary READS(TM) differential display technology, cDNA microarrays, and single gene quantitative PCR), with comprehensive information on samples, clinical profiles and rich gene annotations.

The GeneExpress 2000 database suite is based on a three-tier architecture. The components include an Oracle 8.1 database server hosting the data warehouse, a high performance analysis engine providing support for computationally intensive gene expression data mining, and Java client user interfaces providing support for more streamlined user navigation, powerful data manipulation and analysis. Gene Logic's proprietary OPM data management and middle-ware tools provide further support for rapid tuning of the user interface for improved performance and usability. The GeneExpress 2000 also provides an enhanced Workspace Manager(TM) supporting a centralized and secure repository for user-defined analysis projects and includes new proprietary analysis tools. An enhanced GeneExpress Index(TM) records annotations for known human, rat, and mouse genes, and provides support for classifying proprietary novel genes. Finally, the GeneExpress 2000 allows users to explore and share massive amounts of gene expression information in a computer network environment including local server and secure remote access.

"The rollout of the GeneExpress 2000 database greatly improves the ability of our current and prospective commercial users to efficiently mine massive amounts of gene expression information," commented Dr. Michael J. Brennan, Chairman and CEO of Gene Logic. "Our data management and software development teams have done an outstanding job in improving our GeneExpress product, allowing us to deliver our unique and high value data content with an impressive and cutting edge data management platform to our commercial customers. This marks the next step in Gene Logic's quest to become the genomic information provider of choice for the pharmaceutical and biotechnology industries."

Gene Logic Overview

Gene Logic Inc. is a leading provider of genomic information, enabling the discovery and development of pharmaceutical, biotechnology, health care, and life science products through the systematic and industrialized application of genomics and bioinformatics.

Gene Logic has built and is commercializing what it believes to be the world's most comprehensive survey of gene expression in human and animal tissues. Gene Logic markets two types of gene expression database products to the global pharmaceutical, biotechnology, health care and life science industries: its custom databases and related software products and its new GeneExpress 2000 reference database suite. The GeneExpress 2000 database suite can be used for a variety of research applications, such as to discover and validate novel drug targets, develop therapeutic compounds and facilitate clinical trials and patient management. Gene Logic has the flexibility of offering the data in different formats for customers requiring different levels of information, and pricing such versions optimally. Since the launch of the first commercial version of the GeneExpress database in November 1999, multiple pharmaceutical and biotechnology companies have subscribed. Gene Logic believes its GeneExpress 2000 database suite will become a fundamental reference source of gene expression information for many scientists engaged in industrial and academic life sciences research.

Customers for Gene Logic's databases and data management software include the following: Aventis (formerly Rhone- Poulenc Rorer Inc.); Aventis CropScience (formerly Hoechst Schering AgrEvo GmbH); Fujisawa Pharmaceutical; Japan Tobacco; Merck & Co.; NeuralStem BioPharmaceuticals, Organon (Akzo Nobel); PE Biosystems; Pfizer; Procter & Gamble Pharmaceuticals; Schering-Plough Research Institute; SmithKline Beecham; Therapeutic Genomics; UCB Pharma; and Wyeth-Ayerst Laboratories (American Home Products).

For more information, visit or call 301-987-1824.
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Publication:Online Product News
Date:Jul 1, 2000

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