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ELAN CORPORATION ANNOUNCES BREAKTHROUGH IN ORAL DELIVERY OF LARGE MOLECULES

 GAINESVILLE, Ga., Oct. 7 /PRNewswire/ -- Elan Corporation plc (AMEX: ELN) today announced a breakthrough in the delivery of Heparin, a widely used anti-coagulant, at a financial community meeting in Atlanta. Presently Heparin requires parenteral administration with corresponding implications for cost and inconvenience for patients and medical staff.
 Oral delivery of large molecules has previously not been available. Elan has used its patented BEODAS technology to deliver orally therapeutically significant levels of heparin in animals.
 Elan's research team are now designing formulations with applications to man and are confident of achieving comparative results.
 Elan's BEODAS technology is intended top produce a new generation of orally administered products. BEODAS is a family of nanoparticles with applications to conventional and macromolecules. The particles are controlled release targetable and mucoadhesive. They provide a stable and protective carrier system for sensitive molecules.
 The BEODAS technology enables Elan to produce particles of sub-one micron (1 million of a meter) in size. Elan believes that the mechanisms involved in the absorption of these are a combination of endocytosis in which the nanoparticles are engulfed by certain cells of the intestinal tract and transport across the junctions between cells.
 Elan Corporation plc is a world leader in the specialized health care field of advanced reformulations and drug delivery, concentrating on improved drug absorption and utilization. Elan operates research and manufacturing facilities in Athlone, Ireland; Gainesville, Ga.; Brea, Calif.; and Cambridge, Mass. in the United States; Enschede, Netherlands; Manila, Philippines and Mezzovico, Switzerland. Currently, 23 products have received regulatory approval for marketing in one or more of 42 countries worldwide.
 -0- 10/7/93
 /CONTACT: Donald E. Panoz, chairman & CEO, or Brian Crotty, vice president-communications, 800-252-3526, both of Elan Corporation/
 (ELN)


CO: Elan Corporation ST: Georgia IN: MCT SU: PDT

TM -- NY086 -- 9982 10/07/93 21:19 EDT
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Publication:PR Newswire
Date:Oct 7, 1993
Words:300
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