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E-Z-EM Introduces NutraPrep Meal Kit for Colon Exam Preparation; Low Residue Foods Replace Liquid Diet for Improved Patient Compliance and Tolerance.

Business & Health Editors

WESTBURY, N.Y.--(BW HealthWire)--Sept. 10, 2001

Patients Preparing for a Colon Exam Need Not Fast With

NutraPrep's Chocolate Energy Bars, Chicken Noodle Soup and Other

Nutritional Products

E-Z-EM, Inc., (AMEX - EZM.A and EZM.B) today announced that it is introducing the first meal kit specially designed to replace a clear liquid diet prior to examination of the colon.

Called NutraPrep(TM), the meal kit contains a full day's worth of shakes, soup, energy bars and chips - all specially prepared to provide essential nutrition and significantly reduce the amount of residue remaining in the bowel after digestion.

Cleansing the colon is a vital step for accurately evaluating the bowel and detecting abnormal growths such as polyps or cancers. But many common foods can leave too much residue in the bowel, which can diminish the diagnostic accuracy of the x-ray or endoscopic examination and may result in the need for the procedure to be cancelled. Patients preparing for a colon examination are therefore restricted to a clear liquid diet of water, clear juices, coffee, tea and broth prior to their procedure.

"Our goal at E-Z-EM is to develop new products that will make the preparation process more patient-friendly," said Anthony A. Lombardo, President and CEO of E-Z-EM. "We're confident that patients will find the NutraPrep meal kit simple to comply with and much more satisfying than a clear liquid diet."

Better than Fasting

"Until now, preparing for a colon exam forced people to fast for an entire day, leaving them weak, hungry and irritable," said Mark DeLegge, MD, Assistant Professor of Medicine in the Gastroenterology department at the Medical University of South Carolina in Charleston.

"Preparation for a colon exam is the number one complaint doctors hear from patients, many of whom do not follow their doctor's advice and eat food that leaves too much residue in the bowel," said Dr. DeLegee. "When the bowel is not properly cleansed the patient has to return to the doctor's office for a second visit, costing the healthcare system money and time. But with specially prepared foods, patients will be able to eat the day before the exam and improve compliance with the preparation process."

Key Clinical Findings

Dr. DeLegge conducted a study comparing the effectiveness of three different bowel preparations among 36 patients. The first group received the NutraPrep meal kit (solid and liquid food) with E-Z-EM's laxative preparation LoSo Prep(TM); the second group took a modified version of NutraPrep (liquid products only) with LoSo Prep; and the third group had a clear liquid diet with sodium phosphate solution (double dose). The study findings, evaluated by two independent endoscopists, revealed significant amounts of retained residue in 50 percent of the patients on the clear liquid diet, but only in 25 percent of patients taking the NutraPrep meal kit. Overall quality was rated as excellent for 66.7 percent of the patients taking the meal kit, compared to only 33.3 percent of patients on the clear liquid diet.

"Our study found that twice as many patients had an excellent bowel prep with the new meal kit versus the standard bowel preparation," said Dr. DeLegge.

Nutritional Chocolate Bars and More

Specially designed by gastroenterologists and nutritionists, NutraPrep foods prepare the colon by leaving a minimal amount of residue in the bowel while providing complete nutritional balance for patients. Each food and beverage has been packaged with easy-to-understand instructions and labeled with icons indicating use at various times of the day: breakfast (sunrise), lunch (full sun) or dinner (moon and stars).

The NutraPrep meal kit contains an assortment of foods, including:
-- 3 vanilla shakes

-- 2 lemon drinks

-- 2 chocolate-flavored energy bars

-- 1 cinnamon apple sauce

-- 1 package of potato snacks

-- 1 chicken noodle soup

-- 1 stroganoff

-- 1 plastic mixing container with cover

NutraPrep can be used in conjunction with a laxative preparation, such as E-Z-EM's LoSo Prep, which contains less than 35 mg of sodium, significantly less than PEG or sodium phosphate preparations. LoSo Prep is a magnesium citrate and bisacodyl-based bowel preparation.

Importance of Cancer Screening

The American Cancer Society estimates that there will be about 98,200 new cases of colon cancer (46,200 men and 52,000 women) diagnosed in the United States in 2001. Research indicates that early detection and intervention can reduce mortality from colon cancer by up to 90 percent while also reducing the incidence of non-colon cancers. Furthermore, the American Cancer Society estimates that nearly 74 million people over age 50 are eligible for colon cancer screening. However, only 20% of this population base is actually screened each year, and many patients of these patients are screened with fecal occult blood tests which can yield less-than-optimal results.

Company Information

E-Z-EM, the world's largest manufacturer of contrast agents for gastrointestinal radiology, has developed the only CT injector on the market that can help detect contrast extravasation, the PercuPump(R) with patented EDA(TM) technology. The Company's wholly owned subsidiary, AngioDynamics, manufactures a wide range of products, including angiographic, thrombolytic, vascular access, and drainage products, as well as stents and medical devices for angioplasty. Enteric Products, Inc., another subsidiary, develops, manufactures and markets tests for detection of the ulcer-causing bacterium Helicobacter pylori. For additional information, please visit

The statements made in this document contain certain forward looking statements that involve a number of risks and uncertainties. Words such as "expects", "intends", "anticipates", "plans", "believes", "seeks", "estimates", or variations of such words and similar expressions, are intended to identify such forward-looking statements. Investors are cautioned that actual events or results may differ from the Company's expectations. In addition to the matters described above, the ability of the Company to develop its products, future actions by the FDA or other regulatory agencies, results of pending or future clinical trials, general market conditions, competition and pricing, as well as the risk factors listed from time to time in the SEC filings of E-Z-EM, Inc., including but not limited to its Annual Report on Form 10-K for the year ended June 2, 2001, may affect the actual results achieved by the Company.
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Publication:Business Wire
Geographic Code:1USA
Date:Sep 10, 2001
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