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DuPont probiotic strain boosts immune function in the elderly.

A collaborative study by DuPont Nutrition & Health and the University of Reading (U.K.) examined the effect of Bifidobacterium lactis Bi-07 on immune function in healthy elderly subjects, and found that consumption of the probiotic strain improved the function of specialized innate immune cells, or phagocytes. Results of the study were published in the Journal of Nutritional Science.

Dr. Markus Lehtinen, senior scientist, DuPont Nutrition & Health explained, 40 healthy elderly volunteers were selected in the double-blinded, placebo-controlled, randomized cross-over study. Volunteers received maltodextrin as a placebo (8 g/day), prebiotic galacto-oligosaccharides (GOS) (8 g/day), probiotic (Bi-07; 109 colony-forming units/day) and synbiotic GOS + Bi-07 (8 g GOS/day and 109 colony-forming units Bi-07/day). Volunteers were randomized to four groups that consumed the study products in random order in four periods. Supplements were provided for 21 days, with a 28-day wash-out period. Blood, saliva and fecal samples were taken from the study subjects to analyze markers of immune function and microbiota composition.

It was found that subjects in the Bi-07 group had higher phagocytic activity of monocytes (p<0.001) and granulocytes (p=0.02) than subjects in the placebo group. Changes in other markers of immune function or microbiota composition were not detected in any supplementation groups.

Researchers concluded that Bi-07 consumption improved innate phagocytic activity of monocytes and granulocytes in healthy elderly. This could be beneficial to elderly who suffer from decreased phagocytic activity and higher susceptibility to infections. For more information:
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Title Annotation:Research Highlights
Publication:Nutraceuticals World
Article Type:Clinical report
Date:Apr 1, 2014
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