Douglas battles through throat cancer to revive Gordon Gekko.
The movie, called Wall Street: Money Never Sleeps, brings back the character of the ruthless corporate raider Gordon Gekko, who became a symbol for the risk-taking culture in global finance.
Despite his battle with throat cancer, for which he is undergoing chemotherapy and radiation treatment, the 65-year-old Hollywood star posed for photos with co-stars including Shia LaBeouf and Carey Mulligan and director Oliver Stone. He did not give any interviews.
The movie's young star LaBeouf called Douglas a "wolf". He said Douglas showed no signs of weakness while making the Wall Street sequel, which opens on Friday.
Stone said that it had been a "struggle" but that the star of the original 1987 Wall Street movie had fought through.
The first film featured Charlie Sheen as a stockbroker hungry for success and won Douglas an Oscar for playing Gekko.
Michael Douglas and Catherine Zeta-Jones at the premiere of Wall Street: Money Never Sleeps in New York. Below, with co-stars Carey Mulligan and Susan Sarandon PICTURE: Rex