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Disseminated cutaneous leishmaniasis: ulcerovegetative and ulcero-crusted lesions.

A 69-year-old male patient, with history of multiple furuncles for two months, without improvement after the use of cephalexin and amoxicillin/clavulanate for 20 days, and daily fever for a week. On dermatological examination, multiple ulcerovegetative and ulcero-crusted cutaneous lesions on the face, ears, scalp, back, upper and lower limbs and genitalia were observed (Figs. 1 and 2). There was no lymphadenopathy. Based on the clinical picture the hypotheses of disseminated cutaneous leishmaniasis, paracoccidioidomycosis, and malignant syphilis were raised. Laboratory tests (blood count, renal function, hepatography, and coagulogram) were normal. Serology for hepatitis, syphilis, HIV, and Leishmania donovani were negative.

Swabs taken from open lesions for direct mycological examination and culture for fungi were negative. Histopathological of the edge of an ulcer on the dorsum demonstrated dense lymphohistiocytic inflammatory infiltrate with plasma and mast cells, in addition to neutrophils and granuloma formation; hyperplastic skin surrounded with areas of pseudoepitheliomatous pattern. Giemsa and Ziehl-Neelsen staining were negative for fungi and acid-fast bacilli, respectively. Rounded and oval structures with kinetoplast, phagocytosed in macrophages were observed.

Based on clinical and histological picture of chronic ulcerated dermatitis associated with leishmanias, the diagnosis of disseminated cutaneous leishmaniasis was established, the treatment with meglumine antimoniate 20mg/kg/day was started, and administered for 30 days. After 20 days of the end of treatment, there was healing of skin and mucosal lesions. He is in the ninth month of follow-up, with no appearance of new lesions and complications (Fig. 3).

A negative serology for L. donouani came as no surprise, as this agent causes visceral leishmaniasis, with rare cases of skin lesions described in the literature. (1,2) Currently considered an emerging form of the disease, (3) disseminated leishmaniasis should be detected early, recognizing its clinical spectrum and disabling potential.




Conflicts of interest

The authors declare no conflicts of interest.


(1.) Bernardes Filho F, Bonatto DC, Martins G, Maier LM, Nery JAC, Azulay-Abulafia L. Occurrence of two autochthonous cases of American cutaneous leishmaniasis in the neighborhood of Caju, city of Rio de Janeiro, Brazil. An Bras Dermatol. 2014;89:848-50.

(2.) Gelanew T, Hurissa Z, Diro E, et al. Disseminated cutaneous leishmaniasis resembling post-kala-azar dermal leishmaniasis caused by Leishmania donovani in three patients co-infected with visceral leishmaniasis and human immunodeficiency virus/acquired immunodeficiency syndrome in Ethiopia. Am J Trop Med Hyg. 2011;84:906-12.

(3.) Vernal S, De Paula NA, Gomes CM, Roselino AM. Disseminated leishmaniasis by Leishmania viannia subgenus: a series of 18 cases in southeastern Brazil. Open Forum Infect Dis. 2016;3:ofv184.

Isabela Martins Sgarbi (a), Flavia da Silva Domingos Santos (a), Veridiana Elisa Monteiro (a), Silvia Nunes Szente Fonseca (b), Fred Bernardes Filho (a,*)

(a) Hospital Sao Francisco, Departamento de Medicina Interna, Ribeirao Preto, SP, Brazil

(b) Hospital Sao Francisco, Departamento de Doencas Infecciosas e de Controle de Infecoes, Ribeirao Preto, SP, Brazil


Article history:

Received 7 October 2016

Accepted 26 October 2016

Available online 21 December 2016

(*) Corresponding author.

E-mail address: (F. Bernardes Filho).

1413-8670/[c] 2016 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. This is an open access article under the CC BY-NC-ND license (
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Title Annotation:Clinical image
Author:Sgarbi, Isabela Martins; da Silva Domingos Santos, Flavia; Monteiro, Veridiana Elisa; Fonseca, Silvi
Publication:The Brazilian Journal of Infectious Diseases
Article Type:Case study
Date:Mar 1, 2017
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