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Disposition of Toxic Drugs and Chemicals in Man, Seventh Edition.

Disposition of Toxic Drugs and Chemicals in Man, Seventh Edition. Randall C. Baselt. Foster City, CA: Biomedical Publications, 2004, 1250 pp., $139.50, hardcover. ISBN 09626523-6-9.


Just as mention of "Tietz" is sufficient shorthand for the venerable comprehensive clinical chemistry text, toxicologists immediately recognize "Baselt" as a definitive source of information for drugs and chemicals encountered as toxins. This seventh edition appears only 2 years after the previous edition, and it continues the pattern of inclusion of new chemicals (139 in this case), including herbal medicines, animal toxins, pesticides, and drugs. The increase of only 100 pages from the previous edition is accomplished by a slight decrease in type size, a change that was not noticeable to this reviewer.

The format remains that of previous editions. Chemicals are covered alphabetically with each entry covering one to three pages. An addendum contains those chemicals apparently added late in the publishing cycle, which in this edition are aripi-prazole, atomoxetine, embutramide, epoetin alfa, escitalopram, tadalafil, and taxine. The contents at the beginning list page numbers for the chemicals as they appear in the book, but the reader may find the index at the end more helpful because its alphabetical listing includes those chemicals in the addendum and also contains multiple page listings for classes of chemicals such as benzodiazepines, chemical warfare agents, chemotherapeutic agents, metals, and quaternary ammonium compounds.

Each entry begins with the chemical structure and the following pharmacokinetic data: half-life, volume of distribution, fraction of protein-bound drug, and pKa. Concise, relevant information is listed under the following subheadings: occurrence and usage, blood concentrations, metabolism and excretion, toxicity, analysis, and references. Blood con centrations are based on dosage studies, and the toxicity section contains body fluid and/or tissue concentrations after reported overdose cases. The analysis section includes pertinent specimen handling and storage information as well as methodologies for analysis. References for each chemical are cited in the text (surname and year) and listed alphabetically at the end of each section. Pharmacogenetics is mentioned in the preface and occasionally in the discussion of metabolism, and it is this reviewer's hope that the next edition will routinely include the pharmacogenetic routes of metabolism and elimination as they become known for each entry.

The information for each chemical is extensive but not exhaustive, and if the answer to one's question is not found here, the references are helpful for further research. This book continues to be one of the most useful initial references for laboratorians and will help answer almost all questions concerning potential poisoning. It remains one of the required books for every toxicologist's library.

Larry Broussard

Louisiana State University

Health Sciences Center

Clinical Laboratory Sciences

New Orleans, LA 70112-2262
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Author:Broussard, Larry
Publication:Clinical Chemistry
Date:Mar 1, 2005
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