Differentiation and Function of T Cell Subsets in Infectious Diseases.
In this special issue, a total of 15 manuscripts were received and eight manuscripts have been accepted for publication after several rounds of review. Three of these publications are review articles that provide comprehensive information regarding the role of innate and adaptive T cells in infectious diseases. R. Zheng et al. generated a metaanalysis by searching published articles identified as relating to the clinical features of human brucellosis in China. They described a significant decrease of [CD4.sup.+], but increase of [CD8.sup.+] T cells, as well as a reduction of [CD4.sup.+]/[CD8.sup.+] ratio in the blood of human brucellosis patients compared to healthy subjects. D. A. Cronkite and T. M. Strutt focus on the regulation of inflammation by lymphocytes. The recent advancements in our understanding of inflammatory triggers, imprinting of the innate immune responses, and the role of T cell memory in regulating inflammation are discussed in this review paper. In particular, the field of innate immune cell memory must be further investigated in order to effectively implement this new insight into vaccine design and clinical therapy for infectious diseases. Y. Zhao et al. explore the role of [gamma][delta] T cells in different infections and their potential application in the clinic. They focus on various subsets of [gamma][delta] T cells, which play a critical role in regulating host immunity against pathogens, including bacteria, viruses, and parasites. Since [gamma][delta] T cells are involved in the elimination of pathogens, this cell type might have promising implications for the treatment of infectious diseases in preclinical studies.
Among the five research articles in this special issue, three manuscripts from Chinese research groups are associated with Schistosoma or Schistosoma/HIV coinfection. Y. Zhu et al. demonstrated that the administration of pioglitazone, which is an agonist of peroxisome proliferator-activated receptor- (PPAR-) [gamma], reduces splenic and hepatic immunopathogenesis in Schistosoma japonicum-infected mice through inducing Treg cells. Moreover, PPAR-[gamma]-agonist can promote Foxp3 expression through both macrophage-dependent and independent manners. Y. Yang et al. demonstrate that the [CD4.sup.+]/[CD8.sup.+] T cell ratio is lower in Schistosoma/HIV coinfection patients compared with levels in patients with HIV- or Schistosoma-infection only. This result suggests significant immune suppression in coinfection patients. X. Chen et al. determine that Good's syndrome (GS) patients have an inverted ratio of [CD4.sup.+]/ [CD8.sup.+] T cells, more Treg cells, and a lower percentage of V[gamma]2 subpopulation in T cells in the blood. In particular, [CD4.sup.+] T cells from GS patients show an insufficient ability to proliferate and express higher levels of PD-1, explaining the impaired [CD4.sup.+] T cell responses in GS patients.
There are two manuscripts that are not directly linked to the study of T cells but highlight the important immune components that can regulate T cell responses. R. C. Araujo et al. detected an increased level of human leukocyte antigen E (HLA-E) in hepatocytes and Kupffer cells of HCV patients compared with that in health people. Since HLA-E can bind and present peptides to antigen-specific [CD8.sup.+] T cells, it may play a role in regulating T cell activation in HCV patients. J. Qu et al. underscore the immunomodulatory role of Toll-like receptor (TLR3) in NK cells. They demonstrate that TLR3+ NK cells display activated phenotypes as evidenced by upregulated surface activation markers and increased cytokine production. Although TLR3 expression is comparable on T cells after Schistosoma infection, TLR3dependent NK cell activation may regulate T cell responses through cell-cell interaction and the cytokine microenvironment in lymphoid organs.
In summary, this special issue covers several important aspects of T cell functions related to infectious diseases. We hope that these articles can provide guidance for further research on T cell functions and effective therapeutics.
Conflicts of Interest
None of the authors of this paper has a financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of this paper.
We would like to thank all the authors who submitted their high-quality manuscripts to this special issue and provided new insights into T cell study. We would like to thank the reviewers and editors, who made great efforts to improve the quality of this special issue. We also thank Dr. Linsey Yeager for assistance with manuscript preparation.
Yuejin Liang (ID), (1) Xiaojun Chen (ID), (2) Jinling Chen, (3) and Fengliang Liu (1)
(1) Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas 77550, USA
(2) Department of Pathogen Biology & Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu 210019, China
(3) Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu 226001, China
Correspondence should be addressed to Yuejin Liang; firstname.lastname@example.org
Received 19 August 2018; Accepted 19 August 2018; Published 23 September 2018
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|Author:||Liang, Yuejin; Chen, Xiaojun; Chen, Jinling; Liu, Fengliang|
|Publication:||Journal of Immunology Research|
|Date:||Jan 1, 2018|
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