Dieulafoy disease of the colon.
Dieulafoy disease is also known as Dieulafoy lesion or ulcer, caliber persistent artery, gastric aneurysm, gastric arteriosclerosis, submucosal arterial malformation, cirsoid aneurysm, and solitary exulceration simplex. The most common location is the lesser curvature of stomach, within 6 cm of the cardia. The reason for the predominance of location at this site is that the submucosal arteries in the lesser curvature are direct branches of the left gastric artery, whereas in the rest of the stomach, the submucosal vessels are of much smaller caliber because of their serial branching. Interestingly, coexistence of the lesion with prior gastric surgery has been noted with increased frequency. (4) The cause of the disease is unknown, with some believing it could be congenital, whereas others propose it to be an acquired condition. (2,4,5)
Of late, there have been increasing reports of extragastric Dieulafoy disease. It has been reported in the lip, esophagus, duodenum, jejunum, ileum, cecum, right transverse, left colon, rectum, (2) anal canal, (3) gall bladder, and bronchus. In fact, one-third of cases in a recent series were extragastric in location.6 Barbier (7) reported colonic Dieulafoy disease for the first time in 1985. Since then, 10 cases have been reported in colon, with 9 involving the right colon. (1,2,8,9) Thus, left-sided colonic involvement is quite rare.
The disease usually occurs in males, and there is a wide age range at time of occurrence, with reports of cases occurring in infants as well as individuals up to 93 years old. (2) The presentation in all ages is the same, with sudden onset of extensive bleeding. Because the bleeding is arterial, the amount of blood lost is large. The bleeding is usually intermittent, and even if it stops spontaneously, the likelihood that the patient will rebleed is high. Depending upon the site of bleeding, the patients present with hematemesis, melena, hematochezia, hemoptysis, or hemodynamic instability only. There is a report of a patient bleeding from a surgically created rectal mucous fistula. (10)
Although Dieulafoy disease has no direct disease associations, alcohol intake and nonsteroidal antiinflammatory drug use are said to increase the chances of bleeding from a gastric lesion by causing mucosal erosions. In the colon, solid bowel contents lead to stercoral ulceration with resultant exposure of the abnormal artery and hemorrhage. (2) There are reports of Dieulafoy disease occurring in patients with classic polyarteritis nodosa (11) and abnormal von Willebrand factor. (12) Interestingly, there have been 3 recurrences, to our knowledge, of Dieulafoy lesion. (11)
In 1962, Voth (13) put forward the theory of the caliber persistent artery. Voth postulated that the artery fails to taper as it reaches the mucosa but is otherwise normal. Miko and Thomazy, (5) who carried out measurements of the diameter of mucosal and submucosal arteries of patients with Dieulafoy lesion as well as control subjects, support that theory. The mean diameter of pathologic arteries at the level of muscularis mucosae was found to be 1.08 mm (0.39 SD), versus normal arteries having 0.1 mm (0.01 SD) diameter. By serial sectioning, they also demonstrated that there is an accompanying vein, which may also play a role in bleeding.
A Dieulafoy lesion remains asymptomatic unless mucosal erosion exposes the underlying artery, causing it to bleed. Normally, a network of musculoelastic fibers surrounds and tethers the big branches of arteries entering the submucosa to the muscularis propria. Because the artery reaches close to the muscularis mucosae in Dieulafoy disease, such fibers hold the artery to the muscularis mucosae as well. There is no free, overlying submucosa to allow movement of the mucosa over the submucosa, and the pulsations of the artery cause mucosal damage. Mucosal erosions expose the artery, predisposing it to further injury and bleeding. Also, the artery raises the mucosa overlying it, making it vulnerable to injury.
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All these studies have been done on gastric lesions. Because gastric and colonic lesions are identical histologically, the same mechanisms may be extrapolated to play a role in colonic Dieulafoy disease.
Macroscopically, dormant colonic Dieulafoy lesion appears like a pseudopolyp at colonoscopy. Characteristically, attempted polypectomy at colonoscopy by electro-snare leads to heavy bleeding. Actively bleeding lesions show arterial spurting, and the caliber of the artery may approach 1 to 2 mm. The mucosal erosion usually measures 3 to 5 mm, and the surrounding mucosa typically appears normal endoscopically. (1-4)
Microscopically, the submucosal artery is seen impinging on, and often eroding through, the muscularis mucosae (Figure 1). Apart from this artery having an abnormally large caliber at this site, there is no obvious abnormality of the arterial wall, and there is no vasculitis. The lesion is usually a single one and always shows an elastic lamina (Figures 2 and 3). Only the overlying mucosa shows erosion, and the surrounding mucosa appears normal histologically. If the artery has bled, an attached thrombus may be seen. No other microscopic abnormalities have been documented, to our knowledge.
The most important differential diagnosis for Dieulafoy disease is angiodysplasia because both are right sided and present with sudden onset of massive lower gastrointestinal bleeding. On angiography, vascular ectasia and arteriovenous shunting is seen in angiodysplasia, but these features are absent in Dieulafoy disease. Histologically, findings of abnormal submucosal arteries and veins are seen in angiodysplasia, whereas Dieulafoy disease is characterized by mucosal erosion overlying an eroded, large, submucosal, abnormally superficial artery.
Dieulafoy disease should also be separated from other causes of lower gastrointestinal bleeding, like diverticular disease; telangiectasias (which may be associated with Osler-Weber-Rendu syndrome, Turner syndrome, and systemic sclerosis); vascular neoplasms; advanced liver disease causing mucosal spider nevi, which can cause bleeding similar to Dieulafoy disease14; and disorders of connective tissues affecting blood vessels. All these conditions can be distinguished from each other on the basis of clinical presentation and endoscopic and angiographic findings, thus making a biopsy rarely necessary.
Dieulafoy disease of the colon is a rare cause of massive lower gastrointestinal hemorrhage. The treatment is endoscopic or arteriographic, and resection is performed in only 5% of cases when control of bleeding has not been achieved by other first-line modalities. (2) Pathologists need to be aware of the existence of this rare entity as a possible cause of extensive lower gastrointestinal tract bleeding and to differentiate it from other etiology.
(1.) Amaro R, Petruff CA, Rogers AI. Rectal Dieulafoy's lesion: report of a case and review of the literature. Dis Colon Rectum. 1999;42(10):1339-1341.
(2.) Chaer RA, Helton WS. Dieulafoy's disease. J Am Coll Surg. 2003;196(2): 290-296.
(3.) Gadenstatter M, Wetscher G, Crookes PF, Mason RJ, Schwab G, Pointner R. Dieulafoy's disease of the large and small bowel. J Clin Gastroenterol. 1998; 27(2):169-172.
(4.) Walmsley RS, Lee Y, Sung JY. Dieulafoy's lesion: a case series study. World J Gastroenterol. 2005;11(23):3574-3577.
(5.) Miko TL, Thomazy VA. The caliber persistent artery of the stomach: a unifying approach to gastric aneurysm, Dieulafoy's lesion, and submucosal arterial malformation. Hum Pathol. 1988;19(8):914-921.
(6.) Norton ID, Peterson BT, Sorbi D, Balm RK, Alexander GL, Gostout CJ. Management and long-term prognosis of Dieulafoy lesion. Gastrointest Endosc. 1999; 50(6):762-767.
(7.) Barbier P, Luder P, Triller J, Ruchi C, Hassler H, Stafford A. Colonic hemorrhage from a solitary minute ulcer: report of three cases. Gastroenterology. 1985;88(4):1065-1068.
(8.) Farrell DJ, Bennett MK. Dieulafoy's vascular malformation as a cause of large intestinal bleeding. J Clin Pathol. 1992;45(4):363-366.
(9.) Bateman AC, Beer TW, Bass PS, Odurny A, Gallagher PJ. Massive arterial hemorrhage from the lower gastrointestinal tract. Histopathology. 1996;29(3): 225-231.
(10.) Abdelmalek MF, Pockaj BA, Leighton JA. Rectal bleeding from a mucous fistula secondary to a Dieulafoy's lesion. J Clin Gastroenterol. 1997;24(4):259-261.
(11.) Maeda K, Hayashi Y, Morita I, et al. Recurrent Dieulafoy's ulcers in the stomach and colonic perforation caused by polyarteritis nodosa: report of a case. Gastrointest Endosc. 2006;63(2):349-352.
(12.) Katsinelos P, Paroutoglou G, Beltsis A, et al. Recurrent colonic Dieulafoy's lesion associated with bizarre vascular malformations and abnormal von Willebrand factor. Acta Gastroenterol Belg. 2005;68(4):443-445.
(13.) Voth D. On the pathogenesis of unusual arterial gastric hemorrhages [in German]. Med Welt. 1962;19:1095-1097.
(14.) Akhras J, Patel P, Tobi M. Dieulafoy's lesion-like bleeding: an underrecognized cause of upper gastrointestinal hemorrhage in patients with advanced liver disease. Dig Dis Sci. 2007;52(3):722-726.
Richa Jain, MBBS, MD; Runjan Chetty, MB, BCh, FRCPC, DPhil
Accepted for publication December 4, 2008.
From the Department of Pathology, University Health Network/University of Toronto, Toronto, Canada.
The authors have no relevant financial interest in the products or companies described in this article.
Reprints: Runjan Chetty, MB, BCh, FRCPC, DPhil, University Health Network, Pathology, 610 University Ave, Ste 4-302, Toronto, ON M5G 2M9, Canada (e-mail: email@example.com).
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|Title Annotation:||Resident Short Reviews|
|Author:||Jain, Richa; Chetty, Runjan|
|Publication:||Archives of Pathology & Laboratory Medicine|
|Date:||Nov 1, 2009|
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