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Diagnostic Value of Prospective Electrocardiogram-triggered Dual-source Computed Tomography Angiography for Infants and Children with Interrupted Aortic Arch.

Byline: Hai-Ou. Li, Xi-Ming. Wang, Pei. Nie, Xiao-Peng. Ji, Zhao-Ping. Cheng, Jiu-Hong. Chen, Zhuo-Dong. Xu

Background: Accurate assessment of intra- as well as extra-cardiac malformations and radiation dosage concerns are especially crucial to infants and children with interrupted aortic arch (IAA). The purpose of this study is to investigate the value of prospective electrocardiogram (ECG)-triggered dual-source computed tomography (DSCT) angiography with low-dosage techniques in the diagnosis of IAA. Methods: Thirteen patients with suspected IAA underwent prospective ECG-triggered DSCT scan and transthoracic echocardiography (TTE). Surgery was performed on all the patients. A five-point scale was used to assess image quality. The diagnostic accuracy of DSCT angiography and TTE was compared with the surgical findings as the reference standard. A nonparametric Chi-square test was used for comparative analysis. P <0.05 was considered as a significant difference. The mean effective radiation dose (ED) was calculated. Results: Diagnostic DSCT images were obtained for all the patients. Thirteen IAA cases with 60 separate cardiovascular anomalies were confirmed by surgical findings. The diagnostic accuracy of TTE and DSCT for total cardiovascular malformations was 93.7% and 97.9% (P > 0.05), and that for extra-cardiac vascular malformations was 92.3% and 99.0% (P < 0.05), respectively. The mean score of image quality was 3.77 [+ or -] 0.83. The mean ED was 0.30 [+ or -] 0.04 mSv (range from 0.23 mSv to 0.39 mSv). Conclusions: In infants and children with IAA, prospective ECG-triggered DSCT with low radiation exposure and high diagnostic efficiency has higher accuracy compared to TTE in detection of extra-cardiac vascular anomalies.


Radiation exposure is the primary concern for computed tomography (CT) examinations in infants and children. Children exposed to significant cumulative dosage could result in radiation-induced chromosomal DNA damage. [sup][1] For cardiac CT angiography (CTA), the tube current output was turned on during the predefined phase of cardiac circle in prospective electrocardiogram (ECG)-triggered mode. Exposure time and radiation dosage were significantly reduced in comparison to conventional retrospective ECG-gating mode. This is important to interrupted aortic arch (IAA) patients characterized by early onset during infancy. There were only a few reports of the diagnosis of IAA by CT. [sup][2],[3],[4],[5],[6] To the best of our knowledge, this was the first study conducted for the purpose of evaluating the diagnostic value of prospective ECG-triggered dual-source CT (DSCT) angiography in comparison with transthoracic echocardiography (TTE), using surgical results as the reference standard.


Ethics statement

The local ethics board gave prior approval to the study. Adverse effects of contrast medium injection and radiation exposure were explained to the guardians of all patients, and written informed consent was obtained from each of them.


From 2012 to 2014, 15 patients with suspected IAA were enrolled in this prospective study. The principal clinical symptoms of these patients included shortness of breath ( n = 14), recurrent respiratory infection ( n = 8), intolerance to feed ( n = 8) and cyanosis ( n = 5). Physical examination discovered 10 patients to have higher blood pressure of the arms than that of the legs and 2 patients with a higher blood pressure of the right arm than that of the left arm and the legs. Exclusion criteria were hypersensitive to contrast media ( n = 2) or nephropathy ( n = 0). Prospective ECG-triggered DSCT were performed on 13 patients after routine TTE examinations, and the interval between these two examinations was <7 days. Surgery was performed on all patients.

Dual-source CT protocol

Examinations were performed using a DSCT scanner (Somatom Definition, Siemens Healthcare, Forchheim, Germany). Sedation was achieved by oral administration of chloral hydrate under the supervision of a pediatrician. All patients were free-breathing during the exam.

The high-concentration contrast material (CM, Iohexol Injection, 350 mgI/ml, Beijing Beilu Pharmaceuticals, Beijing, China) was injected via peripheral veins in the elbow or back of the hand, using a dual-head power injector (Stellant; Medrad, Indianola, PA, USA). The volume of CM was 2 ml/kg of body weight, followed by a normal saline (NS) chaser injection of 1 ml/kg of body weight. The saline chaser was injected to reduce artifacts caused by undiluted intra-vascular CM. Total injection time of CM and NS was 20 s. For example, 20 ml CM and 10 ml NS would be injected to a patient with the weight of 10 kg, with an injection rate of 1.5 ml/s.

Dual-source CT parameters were set as follows: Collimation of 64 x 0.6 mm; slice acquisition, 128 x 0.6 mm by means of a z-flying focal spot; and gantry rotation time, 0.33 s. The tube voltage and tube current were adjusted based on body-weight: <3 kg, 80 kV, 60 mAs; 3.1-6 kg, 80 kV, 80 mAs; 6.1-10 kg, 80 kV, 100 mAs; 10.1-15 kg, 80 kV, 120 mAs; >15 kg, 100 kV, 120 mAs [Table 1]. Prospective ECG-triggered DSCT scan mode was applied with full dose exposure between 38% and 42% of R-R interval. [sup][7] The scan range was from the level of the thoracic inlet to 3-4 cm below cardiac apex. Bolus tracking technique was used to synchronize the contrast medium injection and the CT scan. A four-chamber view was chosen to monitoring its even enhancement, and the scan was triggered manually.{Table 1}

Dual-source CT data postprocessing

The acquired data were reconstructed with a slice thickness of 0.75 mm and an interval of 0.5 mm with a medium smooth-tissue convolution kernel (B26f). Reconstructed images were transferred to a multi-modality workplace (Siemens Healthcare, Forchheim, Germany). Multiple planar reformation (MPR), maximum intensity projection (MIP) and volume rendering (VR) were used for image interpretation. Anatomic classification based on the location of the interruption of aortic arch [sup][3] was used for IAA diagnosis: Type A, at the distal to the subclavian artery; Type B, between the second carotid artery and the ipsilateral subclavian artery; Type C, between two carotid arteries.

Image quality assessment

Subjective image quality was evaluated using a five-grade scoring system: [sup][8]

Grade 1: No useful information obtained.

Grade 2: Poor image quality or lack of anatomical detail; incomplete demonstration of anatomical structures

Grade 3: Fair anatomical clarity; the clinically required anatomical structures could be defined with confidence

Grade 4: Good anatomical clarity; all structures were clearly interpretable

Grade 5: Excellent anatomical clarity; excellent image quality obtained

Image scores equal to or above graded 3 were considered sufficient for diagnostic purpose. [sup][9] All evaluations were conducted by two radiologists, each having more than 2 years of cardiovascular diagnostic experiences, and both were blinded to the results of TTE and surgical findings. Consensus agreement was achieved with regard to any disagreement between the two observers. Both diagnostic efficiency and image quality score were calculated.

Radiation dosage

The parameter of radiation dose length product (DLP) was taken from the scan protocol generated by CT system. The effective radiation dose (ED) delivered from CT examination was calculated according to the age-dependent conversion factor (ED = k x DLP, k = 0.039 for patients of 0-4 months, k = 0.026 for 4 months to 1 year, k = 0.018 for 1-6 years). [sup][10]

Statistical analysis

SPSS Statistics version 17.0 (SPSS, Chicago, IL, USA) was used for statistical analysis. With surgical findings as the gold standard, the sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of DSCT and TTE for IAA along with its accompanied malformations were evaluated separately. Inter-observer agreement for image quality scores was assessed by kappa statistics (? > 0.81, excellent agreement; ? = 0.61-0.80, good agreement). Nonparametric Chi-square test was used for comparative analysis of diagnostic efficiency between DSCT angiography and TTE, and P < 0.05 was considered to be a significant difference.


Diagnostic DSCT angiographic images were obtained from all 13 patients (ages ranged from 23 days to 2 years). Thirteen patients were diagnosed IAA by surgical findings, and a total of 10 intra-cardiac anomalies and 50 extra-cardiac anomalies were confirmed by surgical findings.

Image quality assessment

The mean image quality score was 3.77 [+ or -] 0.83, and distributed as score 2 (1/13, 7.69%), score 3 (3/13, 23.08%), score 4 (7/13, 53.85%) and score 5 (2/13, 15.38%). Agreement on grades of overall image quality between the two observers was good (? = 0.75).

Diagnostic performance

According to surgical findings, 5 patients were diagnosed with Type A IAA and 8 patients with Type B IAA. A total of 60 separate cardiovascular anomalies were proven by surgical results. For intra-cardiac malformations, atrial septal defect (ASD) [Figure 1] was identified in 2 patients, and ventricular septal defect (VSD) was identified in 8 patients. For extra-cardiac malformations, 12 patients were discovered to have pulmonary artery hypertension, 11 patients to have persistent ductus arteriosus [Figure 2], 6 patients to have bronchial artery dilation, 3 patients to have an aberrant right subclavian artery, 1 patient to have an isolated left subclavian artery [Figure 3], 1 patient to have aorta-pulmonary artery collateral circulation and 3 patients were identified having ascending aorta (AA)-descending aorta (DA) collateral circulation. One ASD and one pulmonary artery hypertension were missed, and one pulmonary artery hypertension was misdiagnosed on DSCT images. The TTE misdiagnosed one bronchial artery dilation, and missed one IAA, one ASD, one bronchial artery dilation, two aberrant right subclavian artery, one isolated left subclavian artery, one aorta-pulmoary artery collateral circulation and one AA-DA collateral circulation.{Figure 1}{Figure 2}{Figure 3}

Interrupted aortic arch was taken as an extra-cardiac malformation, the Se, Sp, PPV and NPV for prospective ECG-triggered DSCT scan were 96.7%, 98.8%, 98.3% and 97.6%, respectively. And those for TTE were 86.7%, 98.8%, 98.1% and 91.9%, respectively [Table 2]. The diagnostic accuracies of TTE and DSCT were 93.7% and 97.9%, respectively. There was no significant difference in diagnostic accuracy between DSCT and TTE in IAA with regard to overall malformations ( P > 0.05) and intra-cardiac malformations ( P > 0.05). However, there was a difference between DSCT and TTE in the diagnostic accuracy of extra-cardiac malformation ( P < 0.05).{Table 2}

Radiation dosage

There were 2 patients with the body weight of <3 kg, 9 patients with a body weight of 3.1-6 kg, 1 patient with the body weight of 6.1-10 kg and 1 patient with the body weight of 10.1-15 kg [Table 1]. The mean ED of 13 patients was 0.30 [+ or -] 0.04 mSv (ranging from 0.23 mSv to 0.39 mSv).


Interrupted aortic arch is defined as a complete luminal and anatomic discontinuity between the the ascending and descending aorta, which accounts for 1% of congenital heart disease (CHD). [sup][11] The anatomic classification of IAA used in this study was based on the locations of the interruption, each of which has a different embryological origin: The aortic sac, the fourth arch and the junction of the fourth and sixth arches. [sup][3] In our study, Type B is the most common (8/13, 61.5%), followed by Type A (5/13, 38.5%), which was in line with Celoria and Patton. [sup][12]

Earlier studies showed that IAA was associated with a high mortality rate of > 90% at year of one and the survival time was approximately 4-10 days without treatment. [sup][13],[14] Low birth weight, immediate presentation, Type B IAA, and anomalies primarily associated with cardiac structures, such as initial left ventricular outflow tract, were regarded as high-risk factors for death. In a recent study, 59% patients were reported to survive for 16 years after proper treatment in addition with the improvement of perioperative care, this survival rate was increased up to 70%. [sup][15] The cardiovascular anomalies along with IAA may be more crucial for patient outcome than IAA itself. [sup][16] Thus, an appropriate modality to identify both IAA and other cardiovascular anomalies appeared to be crucial indicators for effective clinical treatment.

Prospective ECG-triggered dual-source CT

Two X-ray tubes of DSCT could provide a high temporal resolution of 83 ms. Shorter scanning time could minimize the breath artifact. Thus, DSCT was helpful for neonates who cannot hold their breath. Besides, prospective ECG-triggered DSCT could permit advance prediction of R-wave. With a sequential prospective mode for data acquisition, full-exposure tube output could be initiated at selected phases, such as 38-42% in this study. Therefore, radiation dosage could be remarkably reduced. Meanwhile, the high performance of DSCT angiograph offered good image quality on heart and complex anatomy of cardiovascular malformation, which could be helpful in the development of more effective surgical plans.

Multiple planar reformation could provide the detail of malformations, and track vascular source and measurement parameters, which are important for clinical therapy (e.g., the distance of VSD, the diameter of AA and main pulmonary artery). MIP could give a holistic view of regions of interests such as the connection of different vessels and blood support of descending artery in one image. VR could visually display a full view of the entire heart and vessels, including for example, the location of the interruption of the aortic arch, and the growth of the aortic artery, pulmonary artery and collateral branches. However, the intra-cardiac structures could not be well displayed on VR images.

Advantages of prospective ECG-triggered dual-source CT

The retrospective ECG-gating with a relatively high radiation dosage might increase the risk of cancer. Brenner and Hall [sup][17] stated that there was direct evidence from epidemiologic studies that organ doses corresponding to common CT study resulted in an increased risk of cancer. Therefore, the development of low-dose techniques was indicated. Prospective ECG-triggered DSCT with a predicted R-R interval for data acquisition could significantly reduce radiation dosage. It was reported that the prospective ECG-gating technique could reduce the radiation burden by more than 80% while maintaining the image quality in comparison with retrospective ECG-gating in cardiac CTA examinations. [sup][18],[19],[20] Our result showed that prospective ECG-triggered DSCT examination could achieve 0.30 mSv of ED while maintaining diagnostic image quality. We chose 38-42% phases of cardiac cycle as full dose exposure as against 75% phase in Earls's research, [sup][21] because of the higher heart rate of patient cohorts enrolled (most were infants).

Comparisons with other imaging modalities

In the past, cardiovascular specialists thought that TTE was the ultimate solution for CHD. It was inexpensive, noninvasive, accessible, and could provide both anatomical and functional information about the heart. [sup][22],[23] TTE also has an advantage in the diagnosis of intra-cardiac deformations. However, for IAA, the accompanied malformations of the aortic arch, pulmonary artery, subclavian artery and bronchial artery, etc . could not be detected well by TTE. [sup][24] The limited spatial resolution of TTE could be resolved by prospective ECG-triggered DSCT. Meanwhile, the limitation of acoustic window for full-view observation of these structures will be overcome by DSCT angiography. This study demonstrated that DSCT held advantages in the diagnosis of extra-cardiac malformations along with IAA.

Magnetic resonance imaging (MRI) is an ionizing radiation-free imaging modality. Foran et al . reported that three-tesla cardiac MRI was feasible in preterm infants without sedation or breath holding. [sup][25] A previous study demonstrated the obtainability of high-quality MR images for CHD, [sup][26] whereas the relatively lower spatial resolution of MRI would be less likely to delineate small malformations such as those of collateral arteries. In contrast to MRI, the higher spatial resolution of DSCT could clearly display the coronary artery as well as collateral branches with diameters <1.0 mm. In addition, the inherent noisier environment, longer examination time, as well as nonavailability of MRI held back its application to infants and children.

Interventional cardiac catheterization (ICC) was regarded as the gold standard for cardiovascular diseases. [sup][24] However, because of the invasive nature, it was far more widely used for treatment than for diagnosis. [sup][27] In addition, the procedure-related mortality in neonatal diagnostic cardiac catheterization remained high, especially for premature and newborn infants. [sup][27],[28]


First, in our study, only end-systolic phase datasets were acquired by prospective ECG-triggered DSCT scan mode. Therefore, the valvular function could not be evaluated. Second, only a small group of patients with IAA confirmed by surgery were included in this study. There might consequently be a certain sample-size bias in the results. A larger sample of patients should be investigated in further research. Third, TTE was used as a comparison, whereas MRI or ICC might be considered as appropriate comparisons in the future.

In infants and children with IAA, prospective ECG-triggered DSCT with low radiation exposure and high diagnostic efficiency has higher accuracy compared with TTE in detection of extra-cardiac vascular anomalies.


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Article Details
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Title Annotation:Original Article
Author:Li, Hai-Ou; Wang, Xi-Ming; Nie, Pei; Ji, Xiao-Peng; Cheng, Zhao-Ping; Chen, Jiu-Hong; Xu, Zhuo-Dong
Publication:Chinese Medical Journal
Article Type:Clinical report
Geographic Code:9CHIN
Date:Sep 1, 2015
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