Development of medical countermeasures to chemical terrorism--the NIEHS's involvement in a government-wide research effort.
As part of the planning for an expanded effort related to chemical agents, the NIEHS and the National Institute on Neurological Diseases and Stroke co-sponsored, in FY 2005, an administrative supplement program to existing grants. The intent of these supplements is to develop improved detection, diagnosis, and treatment strategies for likely chemical threat agents. As a result of this program, NIEHS has funded six supplements for a total of $450,000. The NIEHS supplements went to:
* Paul Bishop and Joseph Caruso, University of Cincinnati, to work on increasing the sensitivity of methods they have developed for detecting hydrolysis products of nerve agents and to extend their analysis to spiked food and water samples
* Brian Day, National Jewish Medical and Research Center, to test the ability of lipoic acid, dihydrolipoic acid, and thioredoxin to reverse or prevent pulmonary injury caused by sulfur mustard
* Richard DiGiulio and Ted Slotkin, Duke University, to study the developmental neurotoxicity of nerve agents and to assess some possible protective treatment strategies
* Clem Furlong, University of Washington, to attempt to increase the activity of human PON1 enzyme to levels sufficient to protect against paraoxon exposure in a mouse model. If successful, he will test the modified enzyme's ability to protect against exposure to sarin, soman, and VX agents in the same mouse model.
* Bruce Hammock and Ian Kennedy, University of California, Davis, to work on the development of miniaturized sensors for use in detecting botulinum toxin, ricin, and abrin
* Cary Pope, Oklahoma State University, to study the differential toxicity of the organophosphorus pesticides chlorpyrifos and parathion, as well as the threat agents sarin and soman, and their inhibition of acetylcholinesterase and the accumulation of acetylcholine in a cannulated rat brain model
This administrative supplement program for selected grant mechanisms funded by NIEHS has just been reannounced for FY 2006 in the NIH Guide (http://grants.nih.gov/grants/guide/notice-files/NOT-ES-06-001.html).
Dennis Lang, PhD | firstname.lastname@example.org
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|Title Annotation:||Announcements / NIEHS Extramural Update|
|Publication:||Environmental Health Perspectives|
|Date:||Nov 1, 2005|
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