Dettori chasing sixth St Leger win.
A race that is steeped in history, the one-mile-six-furlong contest was established in 1776 and boasts some excellent stories in its lengthy history.
Frankie Dettori has won three of the last five renewals and will be hoping Rewilding can help him to a sixth triumph overall this time.
He had to settle for second on Kite Wood last year as fellow Godolphin inmate Mastery landed the honours, but he looks to have a straightforward choice this time.
Rewilding blasted away his rivals in the Great Voltigeur, traditionally the leading Leger trial, and he is a short-priced favourite for Classic glory.
While he is the dominant force, another thrilling contest could be in the offing if the likes of dual Oaks winner Snow Fairy lines up, while Midas Touch appears to be the leading contender for Aidan O'Brien.
It is a week of fascinating racing on Town Moor, where festivities kick off on Wednesday with a clutch of decent handicaps and the Listed DFS Scarborough Stakes over five furlongs.
Thursday's fare cranks up the gears with the Weatherbys Insurance pounds 300,000 2-Y-O Stakes and the Group Two Park Hill Stakes - the so-called fillies' St Leger. Friday's highlight, among many, is the two-mile-two-furlong Doncaster Cup, which is also set to attract top stayers, including Jamie Osbourne's stable star Geordieland.
Throw in the DFS May Hill Stakes and the Flying Childers - both celebrated Group Two heats in their own right - and it should be a cracking afternoon of sport.
Supplementing the Leger on Saturday, of course, is the DFS Champagne Stakes, the Ladbrokes Portland Handicap and the DFS Park Stakes over seven furlongs.
The Curragh host the Irish Field St Leger next Saturday, with Dermot Weld's Profound Beauty a possible contender.
The Rosewell handler also has a second string to his bow in surprise Ascot Gold Cup hero Rite Of Passage, who is still among the possibles.
To round off an outstanding week of racing, Longchamp host their important day of Prix de l'Arc de Triomphe trials. Following her mulish display in the Yorkshire Oaks, all eyes will be on Sariska if she lines up in the Prix Vermeille. She could face a rematch with Midday, and added into the mix are the Prix Niel and Prix Foy, the main domestic trials for three-year-olds and older horses respectively.
The Prix Gladiateur could present some pointers for the Prix du Cadran on Arc day, while the Prix du Petit Couvert will shed a little light on the Abbaye picture.
NEXT WEEK'S MEETINGS FIXTURES (FLAT in capitals) Monday: BATH, NEWCASTLE, Newton Abbot Tuesday: GOODWOOD, LINGFIELD, Sedgefield Wednesday: DONCASTER, EPSOM, KEMPTON (evening), Uttoxeter Thursday: BATH, DONCASTER, EPSOM, KEMPTON (evening) Friday: CHESTER, DONCASTER (CH4), SANDOWN, WOLVERHAMPTON (evening) Saturday: CHESTER (CH4), DONCASTER (CH4), GOODWOOD (CH4), KEMPTON (evening), Sandown Sunday: FFOS LAS, GOODWOOD, NEWCASTLE