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Depression not a risk factor for premature ovarian failure.

WASHINGTON -- Depression may not be a risk factor for premature ovarian failure, Dr. Jamie Luff said in a poster presentation at a meeting sponsored by the International Association for Women's Mental Health.

Although depression has been associated with premature ovarian failure, the occurrence of depression after the start of menstrual irregularity suggests that depression itself is not a risk factor, said Dr. Luff of New York University, New York.

In a study of 90 women aged 19-41 years (mean 32.5 years) with premature ovarian failure (POF), 52% had a past history of major depression. Although depression preceded a diagnosis of POF in 68%, it preceded menstrual irregularity in only 23%, she reported.

Smoking and the use of antidepressants--possible risk factors for POF--were rare in the study group. The researchers defined POF as age younger than 40 years, two follicle-stimulating hormone (FSH) levels greater than 40 IU/L, more than 4 months of amenorrhea, and a normal 46,XX karyotype.

At baseline, the patients in the study completed the Structured Clinical Interview for DSM--III (SCID). While receiving hormone therapy for POF, they filled out daily visual analog scale ratings.

Past history of depression was linked to both increased baseline depressive symptoms and increased number of depressive episodes while on hormone therapy, Dr. Luff noted.
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Title Annotation:Women's Health; research report
Author:Splete, Heidi
Publication:Internal Medicine News
Article Type:Brief Article
Geographic Code:1USA
Date:Aug 15, 2004
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