Depression as the First Manifestation in a Young Girl With Juvenile Systemic Lupus Erythematosus.
A 12-year-old girl was admitted with a history of sadness, decreased interest in activities, poor communication, and absences from school, fatigue, irritable moods, and arthralgia in her hands. The patient had not yet had menarche. The symptoms worsened, so the family decided to call for a psychiatric consultation. Given a diagnosis of depression, she was started on treatment with antidepressants without any response. Her depressive symptoms continued, but the family decided not to seek continued medical help. As stated above, after waiting for over a year, she was admitted to another hospital with nephrotic syndrome, anasarca, and a positive antinuclear antibody.
Prednisone 1 mg/kg/day was started and after 30 days, little improvement was seen. She was then transferred to our hospital with periorbital edema and pleural effusion. Urinary analysis revealed microscopic hematuria and proteinuria (24 hour proteinuria was 3814 mg/L) with normal renal function. A written informed consent was obtained from the parents or guardians.
Other laboratory findings included hemoglobin, 7.6 g/dL; white cell count, 10,360/[mm.sup.3] (polymorphonuclear leukocyte count of 9,220/[mm.sup.3]; lymphocyte count of 932/[mm.sup.3]); and platelet count, 356,000/[mm.sup.3]. Erythrocyte sedimentation rate of 120 mm in the first hour with C-reactive protein was 19.0 mg/dL. Immunological investigation revealed antinuclear antibodies 1:640 homogeneous pattern, antidouble stranded deoxyribonucleic acid antibodies 316 UI/mL (<100 UI/mL), and low serum C3 and C4 complement levels.
Renal biopsy showed diffuse proliferative glomerulonephritis, class IV-S (A/C) International Society of Nephrology/Renal Pathology Society, 2004, with activity index of 6 and chronicity index of 2 (Figures 1 and 2). Immunofluorescence staining showed deposits of immunoglobulin M, immunoglobulin G, immunoglobulin A, as well as C3 and C1q in mesangium and capillary loops, with segmental and diffuse distribution. Lupus nephritis was considered, as the patient fulfilled the diagnostic criteria for SLE.
The dose of prednisone was increased to 2 mg/kg/day and pulse with methylprednisolone was started. There was markedly improved clinical response with regression of the depression and anasarca. Cyclophosphamide and methylprednisolone were added, while maintaining continuous oral prednisone.
She had no recurrence of depression during the four-month period follow-up. This case report illustrates the diagnostic challenge in juvenile neuropsychiatric lupus. Early diagnosis and precocious treatment may be important to control disease sequelae and reduce the high morbidity of this disease.
Our case highlights the need for rheumatologists to recognize that depression, in a young female patient without response to antidepressants, could be the first manifestation of JSLE. Identification of SLE-specific biomarkers of depression also has high priority.
Declaration of conflicting interests
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
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Tania Caroline MONTEIRO DE CASTRO,  Ho Chi HSIEN 
 Department of Pediatrics, Hospital Sao Camilo, Sao Paulo, Brazil
 Department of Nephrology, Hospital Sao Camilo, Sao Paulo, Brazil
Received: April 25, 2017 Accepted: April 26, 2017 Published online: September 13, 2017
Correspondence: Tania Caroline Monteiro de Castro, MD, PhD. Rua Camilo Nader, 315/22, 05022-001 Sao Paulo, Brazil. Tel: +5511 98578-8030 e-mail: email@example.com
Caption: Figure 1. Tufts reveal segmental proliferation of mesangial cells and endocapillar with segmental expansion of mesangial matrix and formation of synechiae. There is focal karyorrhexis. Basement membrane does not present significant alterations. Capillary loops have a "wire loop" component.
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|Author:||De Castro, Tania Caroline Monteiro; Hsien, Ho Chi|
|Publication:||Archives of Rheumatology|
|Article Type:||Letter to the editor|
|Date:||Mar 1, 2018|
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