Delivering drugs directly to brain tumors.
Henry Brem, a neurosurgeon at the Johns Hopkins Medical Institutions in Baltimore, is developing small polymer disks containing anticancer drugs for implantation at tumor sites. After removing a tumor, a surgeon can line the cavity with dime-size disks that slowly release tumor toxins directly to cancerous tissue.
This method increases the drug dose at the cancer site while minimizing side effects on the patient's system.
In the laboratory, Brem's team is testing various slow-release polymers, including two polyanhydrides, in conjunction with several FDA-approved anticancer drugs. In the first clinical trial, which included 222 patients at 27 medical centers, polymers containing the anticancer agent carmustine, or BCNU, "significantly prolonged patient survival," says Brem.
"In marked contrast to the many toxic effects commonly experienced by patients treated with systemic or intra-arterial BCNU therapy, no significant adverse effects were associated with these implants," he adds.
Researchers are now planning further clinical studies of polymer implants, using other drugs and stronger doses of BCNU.
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|Title Annotation:||American Association for the Advancement of Science; neurosurgeon Henry Brem developing polymer disks to release anticancer drugs directly into tumor site|
|Article Type:||Brief Article|
|Date:||Feb 24, 1996|
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