Deformities rare in osteopenia.
Moderate to severe vertebral compression deformities are rare in postmenopausal women with osteopenia but no history of fragility fracture, Dr. Angela M. Cheung reported in a poster session at the annual meeting of the International Society for Clinical Densitometry.
In what she said is the first study to describe the prevalence of such deformities in healthy postmenopausal women with osteopenia, Dr. Cheung and her associates conducted a cross-sectional analysis of 439 women in the ongoing 2-year Evaluation of the Clinical Use of Vitamin K Supplementation in Postmenopausal Women with Osteopenia (ECKO) trial.
Of the 48 deformities detected in the study, 45 (94%) were grade 1.
"How does that mild, grade 1 vertebral compression deformity translate to future fracture risk?" Dr. Cheung, osteoporosis program director for University Health Network, Toronto, said. "We'll take a look at that. It's an ongoing study,"
Exclusion criteria included being on an osteoporosis medication, having a clinical fragility fracture, or having a T score of less than -2.0 at the lumbar spine, total hip, or femoral neck. Densitometry was used to measure bone mineral density and to perform a vertebral fracture assessment.
Mean patient age at baseline was 58 years (range 40-82 years), and mean body mass index was 26 kg/[m.sup.2]. The majority of women (88%) were white.
Dr. Cheung said she and her colleagues were surprised to see vertebral compression deformities in women from all age groups. "While we do see a higher percentage of [older] people [with] vertebral compression deformities, we see it in young people, too," she said.
Study limitations were a cross-sectional design and a lack of lateral spine x-rays for comparison.
However, vertebral fracture assessment "has been validated by different groups, and the performance of the test is excellent for grades 2-4 deformities."
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|Title Annotation:||postmenopausal women vertebral compression|
|Publication:||Family Practice News|
|Article Type:||Brief article|
|Date:||Mar 15, 2006|
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