Printer Friendly

DPP-4I Not Tied to Increased Risk of Acute Pancreatitis in Seniors; Among adults with heart disease, risk increased with DPP-4I versus thiazolidinedione not sulfonylureas.

TUESDAY, April 10, 2018 (HealthDay News) -- For older adults, dipeptidyl peptidase 4 inhibitors (DPP-4Is) are not associated with increased risk of acute pancreatitis, according to a study published online April 4 in Diabetes Care.

Jin-Liern Hong, Ph.D., from the University of North Carolina at Chapel Hill, and colleagues examined the risks of acute pancreatitis among U.S. Medicare beneficiaries, aged 66+ years, initiating DDP-4Is versus thiazolidinediones or sulfonylureas. Participants had no history of pancreatic disease or alcohol-related diseases.

The researchers found that the risk of acute pancreatitis was not increased comparing 49,374 DPP-4I initiators with 132,223 sulfonylurea initiators (weighted hazard ratio, 1.01; 95 percent confidence interval, 0.83 to 1.24) and comparing 57,301 DPP-4I initiators with 32,612 thiazolidinedione initiators (weighted hazard ratio, 1.11; 95 percent confidence interval, 0.76 to 1.62). The association was not modified by age and sex. Acute pancreatitis incidence was increased for DDP-4I and sulfonylurea initiators but not for thiazolidinedione initiators (2.3 and 2.4 versus 1.5 per 1,000 person-years, respectively), among patients with cardiovascular disease (CVD). The risk of acute pancreatitis was increased among patients with CVD taking DPP-4Is versus thiazolidinediones (weighted hazard ratio, 1.84; 95 percent confidence interval, 1.02 to 3.35), but not compared to sulfonylureas.

"Our study provides evidence that DPP-4I is not associated with an increased risk of acute pancreatitis in older adults overall," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

COPYRIGHT 2018 HealthDay
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2018 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Physician's Briefings
Date:Apr 10, 2018
Words:258
Previous Article:One Night of Sleep Deprivation Linked to Amyloid-? Burden; Increase in A? burden in right hippocampus and thalamus after one night of sleep...
Next Article:Whole Body CT Doesn't Cut Mortality in Peds Blunt Trauma; No significant difference in mortality for those undergoing whole body CT vs selective CT...
Topics:

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |