Printer Friendly

DNA topoisomerases; methods and protocols.

9781607613398

DNA topoisomerases; methods and protocols.

Ed. by Duncan J. Clarke.

Humana Press Inc.

2009

267 pages

$110.00

Hardcover

QP624

Topoisomerases, along with gyrases, are enzymes that alter the topology of DNA, performing such functions during cell division as DNA replication, transcription, and recombination; and chromosome condensation and segregation. Previous volumes in the series have set out methodologies for investigating the enzymes, and in this one, scientists from various biomedical disciplines focus on methods and protocols that have emerged since those volumes were published, thus providing an addendum rather than an update. The topics include the two-dimensional agarose gel electrophoresis of DNA topoisomers, single-molecule magnetic tweezer studies of type IB topoisomers, binding DNA topoisomers I and II to replication origins, assaying topoisomers II checkpoints in yeast, the cytological analysis of chromosome structural defects that result from topoisomers II dysfunction, and the depletion and mutation of topoisomerase II in animal cells.

([c]2010 Book News, Inc., Portland, OR)

COPYRIGHT 2010 Book News, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2010 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:SciTech Book News
Article Type:Book review
Date:Jun 1, 2010
Words:158
Previous Article:The Dao of neuroscience; combining Eastern and Western principles for optimal therapeutic change.
Next Article:Root cause analysis and improvement in the healthcare sector; a step-by-step guide. (CD-ROM included).
Topics:

Terms of use | Privacy policy | Copyright © 2021 Farlex, Inc. | Feedback | For webmasters |