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DHEA inhibits endothelial inflammation.

Scientists have shown that dehydroepiandrosterone-sulfate (DHEA-S) inhibits inflammation in human endothelial cells. * Inflammation and endothelial dysfunction are intimately connected with atherosclerosis, the root cause of cardiovascular disease.


Investigators hypothesized that DHEA-S reduces inflammation in the vascular endothelium (cells lining blood vessels). They incubated endothelial cells from human aortas with DHEA-S for 48 hours and then exposed the cells to tumor necrosis factor-alpha (TNF-alpha), a known instigator of inflammation. DHEA-S significantly inhibited the subsequent production of inflammatory proteins ordinarily triggered by TNF-alpha.

The results demonstrated the ability of DHEA-S to "directly inhibit the inflammatory process," and showed "a potential direct effect of DHEA-S on vascular inflammation that has implications for the development of atherosclerotic cardiovascular disease," investigators concluded.


* Altman R, Motton DD, Kora RS, Rutledge JC. Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: Roles of PPARalpha and NF-kappaB. Vascul Pharmacol. 2008 Feb-Mar;48(2-3):76-84.
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Title Annotation:IN THE NEWS; dehydroepiandrosterone-sulfate
Author:Kiefer, Dale
Publication:Life Extension
Article Type:Brief article
Geographic Code:1USA
Date:Aug 1, 2008
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