DHEA inhibits endothelial inflammation.
Investigators hypothesized that DHEA-S reduces inflammation in the vascular endothelium (cells lining blood vessels). They incubated endothelial cells from human aortas with DHEA-S for 48 hours and then exposed the cells to tumor necrosis factor-alpha (TNF-alpha), a known instigator of inflammation. DHEA-S significantly inhibited the subsequent production of inflammatory proteins ordinarily triggered by TNF-alpha.
The results demonstrated the ability of DHEA-S to "directly inhibit the inflammatory process," and showed "a potential direct effect of DHEA-S on vascular inflammation that has implications for the development of atherosclerotic cardiovascular disease," investigators concluded.
* Altman R, Motton DD, Kora RS, Rutledge JC. Inhibition of vascular inflammation by dehydroepiandrosterone sulfate in human aortic endothelial cells: Roles of PPARalpha and NF-kappaB. Vascul Pharmacol. 2008 Feb-Mar;48(2-3):76-84.
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|Title Annotation:||IN THE NEWS; dehydroepiandrosterone-sulfate|
|Article Type:||Brief article|
|Date:||Aug 1, 2008|
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