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D-ribose for fibromyalgia/chronic fatigue syndrome.

Forty-one patients (mean age, 48 years) with fibromyalgia and/or chronic fatigue syndrome received, in open-label fashion, D-ribose at a dose of 5 g, three times per day, for a total of 280 g. Significant improvements were seen in all five visual analog scale categories assessed: energy, sleep, mental clarity, pain intensity, and well-being. The absolute improvement on a 1 to 10 scale for the different parameters assessed ranged from 0.7 to 1.7. Side effects included anxiety (n = 1), lightheadedness (n = 1), and increased appetite (n = 1).

Comment: Fibromyalgia and chronic fatigue syndrome are associated with impaired cellular energy metabolism. D-ribose has been shown to increase energy production in the heart and skeletal muscle by providing a substrate for the synthesis of adenine nucleotide, which is, in some circumstances, a rate-limiting factor for the production of ATP. While the results achieved with ribose supplementation were modest, this compound might be useful when used as a component of a comprehensive treatment program.

Teitelbaum JE, et al. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006;12:857-862.
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Title Annotation:Literature Review & Commentary
Author:Gaby, Alan R.
Publication:Townsend Letter
Article Type:Brief article
Geographic Code:1USA
Date:Feb 1, 2008
Words:187
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