Cystatin C predicts CV events.
In 4,637 ambulatory elderly subjects followed for a mean of 7 years, cystatin C was the best predictor of CV events, cardiac mortality, and overall mortality. They were able to define low-risk levels (<1.00 mg/L), intermediate-risk levels (1.00-1.28 mg/L), and high-risk levels (1.29 mg/L or more) of cystatin C, the researchers said (N. Engl. J. Med. 2005;352:2049-60).
In an editorial, Lesley A. Stevens, M.D., and Andrew S. Levey, M.D., both of Tufts-New England Medical Center, Boston, said these results suggest that the higher risk of CVD among elderly patients with kidney disease "may be stronger and occur at higher levels of [glomerular filtration rate] than previously suspected."
All elderly patients should be evaluated for possible kidney disease, and those found to have it "should be considered to be in the highest risk group for [cardiovascular] disease and should receive intensive risk-reduction therapy," they said (N. Engl. J. Med. 2005;352:2122-4).
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|Title Annotation:||CLINICAL CAPSULES|
|Author:||Moon, Mary Ann|
|Publication:||Internal Medicine News|
|Article Type:||Brief Article|
|Date:||Jul 15, 2005|
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