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Corgentech announces patent issuance for E2F transcription factor decoy technology.

Corgentech, Inc. (South San Francisco, CA) a biotechnology company, announced that the United States Patent and Trademark Office has issued United States Patent 6,774,118. The patent covers a method for preventing formation of neointimal thickening leading to restenosis and vessel occlusion with any double-stranded oligonucleotide decoy that binds to the transcription factor, E2F, regardless of the sequence of such decoy. The patent is assigned to Brigham and Women's Hospital (Boston, MA), and is exclusively licensed to Corgentech. E2F is a transcription factor family that is responsible for the activation of genes involved in the growth and proliferation of the smooth muscle cells that can lead to neointimal hyperplasia, plaque build-up, venous graft failure or restenosis.

"We are very pleased by the issuance of the latest, and one of the most fundamental, United States patents protecting our E2F Decoy technology," said John P. McLaughlin, Corgentech's president and chief executive officer. "United States Patent 6,774,118 further solidifies our intellectual property position as we move toward commercial development of our lead product candidate."

In October 2003, Corgentech, Inc. and Bristol-Myers Squibb Company entered into an agreement to jointly develop and commercialize Corgentech's edifoligide (E2F Decoy), a first-of-its-kind treatment currently in Phase III development for the prevention of vein graft failure following coronary artery bypass graft and peripheral artery (i.e., leg) bypass graft surgery.

Corgentech is a biopharmaceutical company engaged in the discovery, development and commercialization of a new class of therapeutics called transcription factor decoys, or TF decoys. We are creating a pipeline of novel therapeutics based on our proprietary TF decoy technology, focused initially on the treatment of cardiovascular disease, inflammatory disease, such as arthritis and dermatitis, and cancer.

Corgentech, Inc.

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Comment:Corgentech announces patent issuance for E2F transcription factor decoy technology.
Publication:BIOTECH Patent News
Article Type:Brief Article
Geographic Code:1USA
Date:Aug 1, 2004
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