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Cook Features Surgisis ES: New Product for the Treatment of Penile Curvature; Surgisis ES Featured at Atlanta Meeting.

ATLANTA -- (AUA Annual Meeting) In conjunction with the American Urological Association's Annual Meeting in Atlanta, Cook Urological today announced that it will highlight a new product, Surgisis(R) ES(TM), for the treatment of Peyronie's disease.

Peyronie's disease, also known as penile curvature, is estimated to affect nearly four out of every 100 males between the ages of 40 and 70. The disease is linked to erectile dysfunction in 20 to 40 percent of the sufferers and is characterized by the formation of a plaque or hardened scar tissue beneath the skin of a man's penis. The scarring is non cancerous and may lead to painful erection and curvature of the penis during erection.

The surgical treatment to correct penile curvature utilizes Surgisis ES, a natural biomaterial that provides a graft that is strong, easy to handle, easy to use, biocompatible and supports the growth of new fully-vascularized host tissue in the penis. Results of research conducted by Dr. L Dean Knoll at the Center for Urological Treatment in Nashville Tennessee showed that penile curvature was surgically corrected with the Surgisis ES graft in 90 percent of the cases studied. Dr. Knoll's study also reported no incidence of penile shortening, pain, infection, hematoma, bulging at the graft site or evidence of a local immunogenic reaction. His study concludes that the ease of handling and surgically placing the Surgisis ES graft combined with no comorbidities from tissue harvesting techniques, coupled with no adverse reactions make Surgisis ES an anatomic and functional tunical substitute.

"Cook's Surgisis ES represents a significant advancement in the treatment of this increasingly diagnosed disease," said Jerry French, Senior Vice President and Global Strategic Business Unit Leader for Cook Urological.

Surgisis ES is made from Cook Biotech's Small Intestinal Submucosa (SIS) technology, a breakthrough innovation for the reinforcement or repair of damaged tissue. SIS is made from the porcine small intestine and is processed to produce a three-dimensional extracellular matrix (ECM) consisting of collagen, non-collagenous proteins and biomolecules.

The SIS graft results in site-specific tissue remodeling, called "smart tissue remodeling," which takes place when the host and the graft become indistinguishable. While synthetic or cross-linked implants can encapsulate and form a barrier to the body's natural defenses, SIS grafts are rapidly infiltrated by the host cells, tissues and blood vessels, becoming accessible to the host immune system.

"We are thrilled with the results of Cook's Surgisis ES in the treatment of penile curvature," said Pete Yonkman, president of Cook Urological. "Products incorporating SIS Technology have been successfully used in many surgical, urological and gynecological applications and procedures. We are excited about bringing SIS Technology to the treatment of penile curvature and furthering Cook Urological's commitment to improving the quality of life for patients."

About Cook Urological

Located in Spencer, Indiana, Cook Urological is a member of the Cook family of companies and is the global headquarters for Cook's Urology and Women's Health divisions. COOK(R) ( is the world's largest privately held medical device manufacturer and is a leading designer, manufacturer and global distributor of minimally invasive medical device technology for diagnostic and therapeutic procedures. Since its founding in 1963, Cook has created innovative technologies for radiology, cardiology, urology, critical care medicine, general surgery, assisted reproduction, gynecology and obstetrics, endovascular medicine, gastroenterology and endoscopy.

About Cook Biotech

COOK SIS products are manufactured by Cook Biotech Incorporated (CBI), located in West Lafayette, IN. CBI was founded in 1995 with shared ownership by Cook Group Incorporated, Purdue Research Foundation and Methodist Hospital/Clarian Health Partners to create commercial medical products from bio-scaffolds such as small intestinal submucosa (SIS).

About Peyronie's Disease

For more information on the Peyronie's disease diagnosis and evaluation, treatments and surgery, visit the National Kidney and Urologic Diseases Information Clearinghouse,
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Publication:Business Wire
Date:May 22, 2006
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